Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.40 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16235763 | 0.84 | SMN1; SMN2 (0.46) | GLAALDH1A1LMNAGAATP53 | |
| SCHEMBL16235298 | 0.80 | FABP4 (0.41) | GLALMNAHSD11B1ACLY | |
| SCHEMBL16236114 | 0.69 | FABP4 (0.40) | LMNAHSD11B1ACLY | |
| SCHEMBL16235080 | 0.69 | SMN1; SMN2 (0.45) | ALDH1A1LMNAGAATP53TSHR | |
| SCHEMBL17485196 | 0.68 | — | — | |
| SCHEMBL23603320 | 0.68 | LMNA (0.56) | GLAALDH1A1LMNASLC12A2SLC12A5 | |
| SCHEMBL16235401 | 0.68 | FABP4 (0.39) | LMNAHSD11B1ACLY | |
| SCHEMBL16234963 | 0.67 | ALDH1A1 (0.48) | ALDH1A1TSHRHSD17B10 | |
| SCHEMBL8377905 | 0.67 | ALDH1A1 (0.50) | GLAALDH1A1LMNASLC12A2SLC12A5 | |
| SCHEMBL23862588 | 0.67 | ALDH1A1 (0.49) | ALDH1A1LMNASLC12A2SLC12A5POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925743-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | Active Biotech AB (SE) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014184234-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2014-11-20 | — | — | WO | disclosed |