Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037083 | 0.84 | ATM (0.40) | ATMTRIM24TRIM33HDAC8TDP1 | |
| SCHEMBL5398380 | 0.78 | SMN1; SMN2 (0.37) | ATMTRIM24TRIM33HDAC8ALDH1A1 | |
| SCHEMBL21727606 | 0.74 | ALDH1A1 (0.37) | ATMALDH1A1 | |
| SCHEMBL5400581 | 0.74 | MAPT (0.42) | ATMHDAC8ALDH1A1 | |
| SCHEMBL30799295 | 0.73 | RAPGEF4 (0.33) | ALDH1A1HSD17B10TDP1 | |
| SCHEMBL31180653 | 0.73 | BRD4 (0.44) | — | |
| SCHEMBL18393939 | 0.69 | ALDH1A1 (0.31) | ALDH1A1HSD17B10TDP1 | |
| SCHEMBL31180683 | 0.69 | BRD4 (0.33) | ALDH1A1TDP1 | |
| SCHEMBL16271028 | 0.69 | — | — | |
| SCHEMBL2072144 | 0.69 | HDAC8 (0.58) | ATMTRIM24TRIM33HDAC8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997011-A1 | SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | Janssen Sciences Ireland UC (IE) | 2016-03-23 | — | — | EP | disclosed |
| WO-2014184350-A1 | SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN R&D IRELAND (IE) | 2014-11-20 | — | — | WO | disclosed |