Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 11/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16236502 | 0.93 | ENPP2 (0.40) | CYP1A2ENPP2LPAR1PLA2G7NPC1 | |
| SCHEMBL16236829 | 0.92 | CYP1A2 (0.41) | CYP1A2ENPP2LPAR1PLA2G7NPC1 | |
| SCHEMBL16236925 | 0.89 | CYP1A2 (0.36) | CYP1A2ENPP2PLA2G7NPC1RAB9A | |
| SCHEMBL16236340 | 0.88 | ENPP2 (0.43) | CYP1A2ENPP2LPAR1PLA2G7NPC1 | |
| SCHEMBL16237501 | 0.87 | RAB9A (0.48) | ENPP2PLA2G7NPC1RAB9AKDM4E | |
| SCHEMBL16236610 | 0.84 | NPC1 (0.49) | PLA2G7NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL16237029 | 0.81 | CYP1A2 (0.41) | CYP1A2PLA2G7NPC1RAB9AKDM4E | |
| SCHEMBL16237209 | 0.80 | PLA2G7 (0.45) | PLA2G7NPC1RAB9ARXFP1 | |
| SCHEMBL16237133 | 0.80 | PLA2G7 (0.36) | PLA2G7NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL16237067 | 0.80 | GRM4 (0.41) | PLA2G7NPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997011-A1 | SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | Janssen Sciences Ireland UC (IE) | 2016-03-23 | — | — | EP | disclosed |
| WO-2014184350-A1 | SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN R&D IRELAND (IE) | 2014-11-20 | — | — | WO | disclosed |