Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 7/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | NQO2 | P16083 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 6/20 | 0.35 |
| ▸ | DRD3 | P35462 | 6/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17698872 | 0.74 | CMA1 (0.57) | PKMTSHRPOLB | |
| SCHEMBL22397857 | 0.68 | ADRB1 (0.54) | ABCG2DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL29353984 | 0.66 | — | — | |
| SCHEMBL8711 | 0.66 | — | — | |
| SCHEMBL14417491 | 0.66 | ABCG2 (1.00) | ABCG2PKMTSHRMAPK1 | |
| SCHEMBL4424499 | 0.66 | — | — | |
| SCHEMBL20918913 | 0.66 | POLB (0.50) | HTR1APKMTSHRGSK3BHTR2A | |
| SCHEMBL27402320 | 0.66 | CYP3A4 (0.47) | ABCG2DRD2HTR1ACYP19A1MAPK1 | |
| SCHEMBL16104143 | 0.65 | MGLL (0.48) | CA12CA1CA2CA9CA14 | |
| SCHEMBL19817380 | 0.65 | PTGS1 (0.49) | CA12CA1CA2CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920070-B2 | Spiro-oxazines, indolinones and preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2018-03-20 | — | — | US | disclosed |
| US-20170174706-A1 | SPIRO-OXAZINES, INDOLINONES AND PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-06-22 | — | — | US | disclosed |
| US-9617280-B2 | Spiro-oxazines, indolinones and preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-04-11 | — | — | US | disclosed |
| US-20160115179-A1 | SPIRO-OXAZINES, INDOLINONES AND PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-04-28 | — | — | US | disclosed |
| WO-2014184808-A1 | SPIRO-OXAZINES, INDOLINONES AND PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2014-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174706-A1 | SPIRO-OXAZINES, INDOLINONES AND PREPARATION THEREOF | NR3C2, AR, REN | ABCG2 307/4885DRD2 522/4885HTR1A 1042/4885 |
| US-20160115179-A1 | SPIRO-OXAZINES, INDOLINONES AND PREPARATION THEREOF | NR3C2, AR, REN | ABCG2 307/4885DRD2 522/4885HTR1A 1042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.