SCHEMBL16239011

SCHEMBL16239011

CC(C)c1ccccc1C(=O)Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2c3CCCC2)cc1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
P2RX4 Q99571 10/20 0.49
AVPR2 P30518 1/20 0.37
OXTR P30559 1/20 0.37
AVPR1A P37288 1/20 0.37
NPC1 O15118 2/20 0.37
ALDH1A1 P00352 2/20 0.37
GAA P10253 2/20 0.37
MAPT P10636 2/20 0.37
RAB9A P51151 2/20 0.37
MAPK1 P28482 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
PTGDR2 Q9Y5Y4 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16238946 0.89 P2RX4 (0.49) P2RX4AVPR2OXTRAVPR1ANPC1
SCHEMBL16239101 0.89 P2RX4 (0.51) P2RX4AVPR2OXTRAVPR1ATDP1
SCHEMBL16239138 0.88 P2RX4 (0.48) P2RX4AVPR2OXTRAVPR1ANPC1
SCHEMBL16239121 0.87 P2RX4 (0.49) P2RX4AVPR2OXTRAVPR1ANPC1
SCHEMBL16239015 0.85 P2RX4 (0.48) P2RX4AVPR2OXTRAVPR1AALDH1A1
SCHEMBL16239149 0.85 P2RX4 (0.48) P2RX4AVPR2OXTRAVPR1ANPC1
SCHEMBL14972595 0.85 P2RX4 (0.51) P2RX4ALDH1A1MAPTNPSR1MEN1
SCHEMBL16239155 0.85 P2RX4 (0.53) P2RX4NPC1MAPTRAB9AMAPK1
SCHEMBL16239705 0.83 P2RX4 (0.71) P2RX4
SCHEMBL30297436 0.83 P2RX4 (0.71) P2RX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11918589-B2 Medicament for treatment of multiple sclerosis NIPPON CHEMIPHAR CO., LTD. (JP) 2024-03-05 US claimed
WO-2023190826-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR SUPPRESSING OR TREATING SYMPTOMS ACCOMPANYING PSEUDO-ALLERGIC REACTIONS 学校法人 高崎健康福祉大学 2023-10-05 WO claimed
US-20230277552-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING, SUPPRESSING, OR TREATING SYMPTOM ASSOCIATED WITH ALLERGIC REACTION NIPPON CHEMIPHAR CO., LTD. (JP) 2023-09-07 US claimed
WO-2023157895-A1 PROPHYLACTIC AGENT OR THERAPEUTIC AGENT FOR ENDOMETRIOSIS OR ADENOMYOSIS 国立大学法人 鳥取大学 2023-08-24 WO claimed
US-20230149421-A1 MEDICAMENT FOR PREVENTING OR TREATING IRRITABLE BOWEL SYNDROME OR INFLAMMATORY BOWEL DISEASE NIPPON CHEMIPHAR CO., LTD. (JP) 2023-05-18 US claimed
WO-2023054578-A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR RESPIRATORY DISEASES 日本ケミファ株式会社 2023-04-06 WO claimed
EP-4129296-A1 DRUG FOR PREVENTION OR TREATMENT OF IRRITABLE BOWEL SYNDROME OR INFLAMMATORY BOWEL DISEASE Università di Pisa (IT) 2023-02-08 EP claimed
EP-3848051-A1 MEDICINE FOR DIABETIC PERIPHERAL NEUROPATHY Nippon Chemiphar Co., Ltd. (JP) 2021-07-14 EP claimed
US-20210121478-A1 MEDICAMENT FOR TREATMENT OF MULTIPLE SCLEROSIS NIPPON CHEMIPHAR CO., LTD. (JP) 2021-04-29 US claimed
US-20200223806-A1 P2X4 RECEPTOR ANTAGONIST NIPPON CHEMIPHAR CO., LTD (JP) 2020-07-16 US claimed
EP-2803662-B1 P2X4 RECEPTOR ANTAGONIST NIPPON CHEMIPHAR CO (JP) 2017-03-01 EP claimed
US-9382236-B2 P2X4 receptor antagonist NIPPON CHEMIPHAR CO., LTD (JP) 2016-07-05 US claimed
US-11918589-B2 Medicament for treatment of multiple sclerosis NIPPON CHEMIPHAR CO., LTD. (JP) 2024-03-05 US disclosed
WO-2023190826-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR SUPPRESSING OR TREATING SYMPTOMS ACCOMPANYING PSEUDO-ALLERGIC REACTIONS 学校法人 高崎健康福祉大学 2023-10-05 WO disclosed
US-20230277552-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING, SUPPRESSING, OR TREATING SYMPTOM ASSOCIATED WITH ALLERGIC REACTION NIPPON CHEMIPHAR CO., LTD. (JP) 2023-09-07 US disclosed
WO-2023157895-A1 PROPHYLACTIC AGENT OR THERAPEUTIC AGENT FOR ENDOMETRIOSIS OR ADENOMYOSIS 国立大学法人 鳥取大学 2023-08-24 WO disclosed
US-20160280667-A1 P2X4 RECEPTOR ANTAGONIST NIPPON CHEMIPHAR CO., LTD (JP) 2016-09-29 US disclosed
US-9382236-B2 P2X4 receptor antagonist NIPPON CHEMIPHAR CO., LTD (JP) 2016-07-05 US disclosed
US-20140357858-A1 P2X4 RECEPTOR ANTAGONIST NIPPON CHEMIPHAR CO., LTD (JP) 2014-12-04 US disclosed
EP-2803662-A1 P2X4 RECEPTOR ANTAGONIST Nippon Chemiphar Co., Ltd. (JP) 2014-11-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210121478-A1 MEDICAMENT FOR TREATMENT OF MULTIPLE SCLEROSIS TRPM4, TRPM7, P2RX3 P2RX4 5/4885AVPR2 706/4885OXTR 2024/4885
US-20160280667-A1 P2X4 RECEPTOR ANTAGONIST P2RX7, P2RX1, P2RX2 P2RX4 6/4885AVPR2 574/4885OXTR 379/4885
US-20140357858-A1 P2X4 RECEPTOR ANTAGONIST P2RX7, P2RX1, P2RX2 P2RX4 6/4885AVPR2 609/4885OXTR 384/4885
US-20200223806-A1 P2X4 RECEPTOR ANTAGONIST P2RX7, P2RX1, P2RX2 P2RX4 6/4885AVPR2 609/4885OXTR 384/4885
US-11918589-B2 Medicament for treatment of multiple sclerosis P2RX3, TRPM4, P2RX4 P2RX4 3/4885AVPR2 761/4885OXTR 2145/4885
US-20230277552-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING, SUPPRESSING, OR TREATING SYMPTOM ASSOCIATED WITH ALLERGIC REACTION P2RX5, P2RX3, P2RX2 P2RX4 4/4885AVPR2 939/4885OXTR 3026/4885
US-20230149421-A1 MEDICAMENT FOR PREVENTING OR TREATING IRRITABLE BOWEL SYNDROME OR INFLAMMATORY BOWEL DISEASE P2RX5, P2RX3, P2RX2 P2RX4 5/4885AVPR2 1406/4885OXTR 3557/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.