Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 4/20 | 0.65 |
| ▸ | CCR2 | P41597 | 3/20 | 0.43 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | F11 | P03951 | 2/20 | 0.33 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.33 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12838 | 0.91 | LDHA (0.65) | LDHACCR2 | |
| SCHEMBL16240031 | 0.87 | LDHA (0.66) | LDHATMPRSS4TP53KDR | |
| SCHEMBL8149 | 0.85 | LDHA (0.79) | LDHACCR2ANO1DHODHDAO | |
| SCHEMBL16240296 | 0.83 | LDHA (0.71) | LDHACCR2ABCB11 | |
| SCHEMBL16240396 | 0.83 | LDHA (0.67) | LDHACCR2PPARGDAOCNR2 | |
| SCHEMBL16240013 | 0.83 | LDHA (0.74) | LDHACCR2ABCB11DAO | |
| SCHEMBL7624 | 0.79 | LDHA (1.00) | LDHACCR2ALDH1A1DAO | |
| SCHEMBL16240393 | 0.78 | LDHA (0.66) | LDHATMPRSS4 | |
| SCHEMBL16240315 | 0.76 | LDHA (0.52) | LDHAALDH1A1 | |
| SCHEMBL16240325 | 0.76 | LDHA (0.52) | LDHATMPRSS4ALDH1A1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140343001-A1 | INDOLE DERIVATIVES INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) | UNIVERSITA DI PISA (IT) | 2014-11-20 | — | — | US | claimed |
| US-20140343001-A1 | INDOLE DERIVATIVES INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) | UNIVERSITA DI PISA (IT) | 2014-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343001-A1 | INDOLE DERIVATIVES INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) | LDHA, LDHB, IDO1 | LDHA 1/4885CCR2 2549/4885TMPRSS4 1700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.