Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 15/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 11/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 9/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16242483 | 0.86 | RORC (0.42) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL3625122 | 0.81 | RORC (0.43) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL3625112 | 0.81 | RORC (0.43) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL4640318 | 0.80 | RORC (0.41) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL3623629 | 0.77 | RORC (0.43) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL3623625 | 0.77 | RORC (0.43) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL3615393 | 0.75 | RORC (0.49) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL3615387 | 0.75 | RORC (0.49) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL3625672 | 0.74 | RORC (0.48) | RORCNR1H3NR1I2NR1H2THRB | |
| SCHEMBL3625677 | 0.74 | RORC (0.48) | RORCNR1H3NR1I2NR1H2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2392567-B1 | BENZOTHIAZINE DERIVATIVES AND THEIR USE AS LXR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2014-11-26 | — | — | EP | disclosed |