Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 14/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 11/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 9/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4640318 | 0.90 | RORC (0.41) | RORCNR1H3NR1I2NR1H2LMNA | |
| SCHEMBL16242273 | 0.86 | RORC (0.44) | RORCNR1H3NR1I2NR1H2LMNA | |
| SCHEMBL3623625 | 0.80 | RORC (0.43) | RORCNR1H3NR1I2NR1H2LMNA | |
| SCHEMBL3623629 | 0.80 | RORC (0.43) | RORCNR1H3NR1I2NR1H2LMNA | |
| SCHEMBL3625112 | 0.77 | RORC (0.43) | RORCNR1H3NR1I2NR1H2LMNA | |
| SCHEMBL3625122 | 0.77 | RORC (0.43) | RORCNR1H3NR1I2NR1H2LMNA | |
| SCHEMBL3615393 | 0.77 | RORC (0.49) | RORCNR1H3NR1I2NR1H2LMNA | |
| SCHEMBL3615387 | 0.77 | RORC (0.49) | RORCNR1H3NR1I2NR1H2LMNA | |
| SCHEMBL3621418 | 0.77 | RORC (0.42) | RORCNR1H3NR1I2NR1H2LMNA | |
| SCHEMBL3621415 | 0.77 | RORC (0.42) | RORCNR1H3NR1I2NR1H2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2392567-B1 | BENZOTHIAZINE DERIVATIVES AND THEIR USE AS LXR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2014-11-26 | — | — | EP | disclosed |