Sugi Predict

Sugi Predict / Compounds / SCHEMBL16242452

SCHEMBL16242452

SCHEMBL16242452

N/C(=N\O)c1ccc(N)c(F)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HDAC1 Q13547 1/20 0.55
▸ HDAC6 Q9UBN7 1/20 0.55
▸ KDM1A O60341 11/20 0.46
▸ ALDH1A1 P00352 1/20 0.45
▸ RECQL P46063 1/20 0.43
▸ LMNA P02545 1/20 0.38
▸ GFER P55789 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ CA12 O43570 1/20 0.37
▸ CA1 P00915 1/20 0.37
▸ CA2 P00918 1/20 0.37
▸ CA4 P22748 1/20 0.37
▸ CA6 P23280 1/20 0.37
▸ CA5A P35218 1/20 0.37
▸ CA7 P43166 1/20 0.37
▸ CA9 Q16790 1/20 0.37
▸ CA14 Q9ULX7 1/20 0.37
▸ CA5B Q9Y2D0 1/20 0.37
▸ GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16242453 1.00 HDAC1 (0.55) HDAC1HDAC6KDM1AALDH1A1RECQL
SCHEMBL8281129 0.84 KDM1A (0.50) HDAC1HDAC6KDM1ARECQLLMNA
SCHEMBL14738905 0.84 KDM1A (0.50) HDAC1HDAC6KDM1ARECQLLMNA
SCHEMBL640673 0.83 CES2 (0.50) KDM1ARECQLLMNAGFERKMT2A
SCHEMBL640674 0.83 CES2 (0.50) KDM1ARECQLLMNAGFERKMT2A
SCHEMBL20580081 0.80 KDM1A (0.68) KDM1ARECQLLMNA
SCHEMBL2772394 0.80 KDM1A (0.68) KDM1ARECQLLMNA
SCHEMBL25384548 0.78 KDM1A (0.45) HDAC1HDAC6KDM1ARECQLLMNA
SCHEMBL22394821 0.78 KDM1A (0.45) KDM1ARECQLLMNAGFERKMT2A
SCHEMBL20244317 0.78 KDM1A (0.45) HDAC1HDAC6KDM1ARECQLLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200138028-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2020-05-07 — — US disclosed
US-20190284148-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2019-09-19 — — US disclosed
WO-2018015449-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2018-01-25 — — WO disclosed
US-9725438-B2 Substituted phenylazole derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-08-08 — — US disclosed
US-9725438-B2 Substituted phenylazole derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-08-08 — — US disclosed
US-9725438-B2 Substituted phenylazole derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-08-08 — — US disclosed
EP-3009433-B1 2-PHENYL-1,3-OXAZOLE AND 5-PHENYL-1,2,4-OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES DAIICHI SANKYO CO LTD (JP) 2017-06-21 — — EP disclosed
EP-2805941-B1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO CO LTD (JP) 2016-08-17 — — EP disclosed
EP-3009433-A1 2-PHENYL-1,3-OXAZOLE AND 5-PHENYL-1,2,4-OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES Daiichi Sankyo Company, Limited (JP) 2016-04-20 — — EP disclosed
US-20160090375-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-31 — — US disclosed
US-20160081993-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-24 — — US disclosed
US-20160081993-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-24 — — US disclosed
US-20160081993-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-24 — — US disclosed
US-9233958-B2 Substituted phenylazole derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-01-12 — — US disclosed
US-9233958-B2 Substituted phenylazole derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-01-12 — — US disclosed
US-9233958-B2 Substituted phenylazole derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-01-12 — — US disclosed
US-20140357675-A1 Substituted Phenylazole Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-12-04 — — US disclosed
US-20140357675-A1 Substituted Phenylazole Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-12-04 — — US disclosed
US-20140357675-A1 Substituted Phenylazole Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-12-04 — — US disclosed
EP-2805941-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-11-26 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190284148-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES PRF1, ARG1, NOX1 HDAC1 581/4885HDAC6 736/4885KDM1A 882/4885
US-20200138028-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES PRF1, NOX1, ARG1 HDAC1 551/4885HDAC6 610/4885KDM1A 850/4885
US-20160081993-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE IAPP, SLC5A1, GPR119 HDAC1 99/4885HDAC6 352/4885KDM1A 1008/4885
US-20160090375-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE IAPP, SLC5A1, GPR119 HDAC1 99/4885HDAC6 352/4885KDM1A 1008/4885
US-20140357675-A1 Substituted Phenylazole Derivatives IAPP, SLC5A1, GPR119 HDAC1 109/4885HDAC6 371/4885KDM1A 1022/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.