Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | FOLH1 | Q04609 | 5/20 | 0.47 |
| ▸ | NAALAD2 | Q9Y3Q0 | 4/20 | 0.47 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.43 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.43 |
| ▸ | ITGAL | P20701 | 2/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16246098 | 1.00 | KDM4E (0.54) | KDM4EHPGDFOLH1NAALAD2RIMKLA | |
| SCHEMBL18912366 | 0.83 | ACACB (0.52) | NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL31741254 | 0.78 | ALDH1A1 (0.54) | KDM4EHPGDFOLH1NAALAD2RIMKLA | |
| SCHEMBL1603738 | 0.75 | TSHR (0.51) | KDM4EHPGDFOLH1NAALAD2RIMKLA | |
| SCHEMBL16264928 | 0.75 | NPC1 (0.43) | NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL27806351 | 0.74 | CYP3A4 (0.60) | CA2CA1 | |
| SCHEMBL16246085 | 0.73 | TDP1 (0.50) | KDM4EHPGDFOLH1NAALAD2RIMKLA | |
| SCHEMBL16245945 | 0.73 | KDM4E (0.50) | KDM4EHPGDFOLH1NAALAD2RIMKLA | |
| SCHEMBL23303777 | 0.72 | CA2 (0.62) | KDM4EHPGDFOLH1NAALAD2RIMKLA | |
| SCHEMBL18912264 | 0.72 | ALDH1A1 (0.51) | KDM4EHPGDNPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160075667-A1 | COMPOSITIONS AND METHODS FOR CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) MAGNETIC RESONANCE IMAGING (MRI) | UNIV JOHNS HOPKINS (US) | 2016-03-17 | — | — | US | disclosed |
| WO-2014182538-A1 | COMPOSITIONS AND METHODS FOR CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) MAGNETIC RESONANCE IMAGING (MRI) | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-11-13 | — | — | WO | disclosed |
| WO-2014182538-A1 | COMPOSITIONS AND METHODS FOR CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) MAGNETIC RESONANCE IMAGING (MRI) | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075667-A1 | COMPOSITIONS AND METHODS FOR CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) MAGNETIC RESONANCE IMAGING (MRI) | SLC46A1, SLC5A7, SLCO1B1 | KDM4E 3184/4885HPGD 1600/4885FOLH1 903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.