Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 17/20 | 0.62 |
| ▸ | BRD2 | P25440 | 6/20 | 0.62 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.59 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12487 | 0.82 | NPC1 (0.69) | BRD4BRD2CREBBPBRD3NPC1 | |
| SCHEMBL980536 | 0.79 | MAP4K4 (0.76) | BRD4BRD2CREBBPBRD3NPC1 | |
| SCHEMBL16404612 | 0.79 | BRD4 (0.62) | BRD4BRD2CREBBPBRD3NPC1 | |
| SCHEMBL9657290 | 0.79 | BRD4 (0.62) | BRD4BRD2CREBBPBRD3NPC1 | |
| SCHEMBL5714189 | 0.78 | BRD4 (0.61) | BRD4BRD2CREBBPBRD3NPC1 | |
| Hydrochloric Acid SCHEMBL1016039 | 0.78 | MAP4K4 (0.73) | BRD4BRD2CREBBPBRD3NPC1 | |
| 3,5-Dimethyl-4-Phenylisoxazole SCHEMBL12134072 | 0.77 | BRD4 (1.00) | BRD4BRD2CREBBP | |
| SCHEMBL24726640 | 0.77 | BRD4 (0.78) | BRD4BRD2CREBBPBRD3NPC1 | |
| SCHEMBL10145031 | 0.77 | BRD4 (0.59) | BRD4BRD2CREBBPBRD3NPC1 | |
| SCHEMBL19754248 | 0.76 | BRD4 (0.67) | BRD4BRD2CREBBPBRD3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994469-A1 | BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | Gilead Sciences, Inc. (US) | 2016-03-16 | — | — | EP | disclosed |
| WO-2014182929-A1 | BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES, INC. (US) | 2014-11-13 | — | — | WO | disclosed |