SCHEMBL16246760

SCHEMBL16246760

COc1ccc2cc(OC(=O)O)n(C)c2c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.51
MTNR1A P48039 7/20 0.50
MTNR1B P49286 7/20 0.50
KDM4E B2RXH2 2/20 0.49
ALDH1A1 P00352 1/20 0.49
HPGD P15428 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
HSD17B10 Q99714 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.46
AKR1C3 P42330 4/20 0.42
AKR1C2 P52895 4/20 0.42
PTGS1 P23219 3/20 0.42
PTGS2 P35354 3/20 0.41
CDC42 P60953 1/20 0.41
RAC1 P63000 1/20 0.41
CYP1A2 P05177 1/20 0.41
TSHR P16473 1/20 0.41
SLC22A6 Q4U2R8 1/20 0.41
CCR9 P51686 1/20 0.41
CCR2 P41597 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9235979 0.88 KDM4E (0.64) KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10
SCHEMBL1144942 0.78 KDM4E (0.77) CA2MTNR1AMTNR1BKDM4EALDH1A1
SCHEMBL4198025 0.78 MCL1 (0.57) KDM4EALDH1A1HPGD
SCHEMBL29187769 0.76 ALDH1A1 (0.60) MTNR1AMTNR1BKDM4EALDH1A1HPGD
SCHEMBL17324790 0.75 KDM4E (0.59) CA2MTNR1AMTNR1BKDM4EALDH1A1
SCHEMBL2277189 0.75 L3MBTL1 (0.58) CA2MTNR1AMTNR1BKDM4EALDH1A1
SCHEMBL6223731 0.75 CYP19A1 (0.40) KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10
SCHEMBL2272634 0.74 L3MBTL1 (0.80) CA2MTNR1AMTNR1BKDM4EALDH1A1
SCHEMBL7321176 0.74 KDM4E (0.50) KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10
SCHEMBL435333 0.72 CA2 (0.57) CA2MTNR1AMTNR1BKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2999469-A1 PHARMACEUTICAL COMPOSITION AND THE USE THEREOF, AND APPLICATION REGIME OF SAID PHARMACEUTICAL COMPOSITION FOR ON-DEMAND CONTRACEPTION Bayer Pharma Aktiengesellschaft (DE) 2016-03-30 EP disclosed
WO-2014187744-A1 PHARMACEUTICAL COMPOSITION AND THE USE THEREOF, AND APPLICATION REGIME OF SAID PHARMACEUTICAL COMPOSITION FOR ON-DEMAND CONTRACEPTION BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2014-11-27 WO disclosed