Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 6/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | JAK1 | P23458 | 3/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19659204 | 0.85 | EGLN2 (0.68) | EGLN2JAK1NUDT1JAK2JAK3 | |
| SCHEMBL2250300 | 0.81 | NUDT1 (0.73) | EGLN2POLBJAK1NUDT1JAK2 | |
| SCHEMBL2252969 | 0.81 | EGLN2 (0.54) | EGLN2POLBJAK1NUDT1JAK2 | |
| SCHEMBL16248945 | 0.80 | EGLN2 (1.00) | EGLN2JAK1NUDT1JAK2 | |
| SCHEMBL22888050 | 0.79 | EGLN2 (0.52) | EGLN2JAK1NUDT1JAK2JAK3 | |
| SCHEMBL16248944 | 0.76 | EGLN2 (0.57) | EGLN2JAK1NUDT1JAK2 | |
| SCHEMBL19659256 | 0.75 | EGLN2 (0.56) | EGLN2JAK1NUDT1JAK2JAK3 | |
| SCHEMBL19659225 | 0.74 | EGLN2 (0.55) | EGLN2JAK1NUDT1JAK2FYN | |
| SCHEMBL2145331 | 0.74 | JAK2 (0.60) | JAK1NUDT1JAK2JAK3PTK2 | |
| SCHEMBL16248947 | 0.73 | JAK2 (0.63) | EGLN2JAK1NUDT1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889673-B2 | Triazolopyridine JAK inhibitor compounds and methods | GENENTECH, INC. (US) | 2014-11-18 | — | — | US | disclosed |