Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 5/20 | 0.57 |
| ▸ | JAK2 | O60674 | 5/20 | 0.43 |
| ▸ | JAK1 | P23458 | 4/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3212521 | 0.81 | NUDT1 (0.67) | EGLN2JAK2JAK1NUDT1DYRK3 | |
| SCHEMBL19659204 | 0.80 | EGLN2 (0.68) | EGLN2JAK2JAK1NUDT1DYRK1A | |
| SCHEMBL16248930 | 0.76 | EGLN2 (0.67) | EGLN2JAK2JAK1NUDT1 | |
| SCHEMBL16248947 | 0.75 | JAK2 (0.63) | EGLN2JAK2JAK1NUDT1 | |
| SCHEMBL22888050 | 0.74 | EGLN2 (0.52) | EGLN2JAK2JAK1NUDT1PDE4B | |
| SCHEMBL19659256 | 0.74 | EGLN2 (0.56) | EGLN2JAK2JAK1NUDT1 | |
| SCHEMBL16248945 | 0.73 | EGLN2 (1.00) | EGLN2JAK2JAK1NUDT1 | |
| SCHEMBL19659225 | 0.73 | EGLN2 (0.55) | EGLN2JAK2JAK1NUDT1 | |
| SCHEMBL3104872 | 0.71 | NUDT1 (0.69) | EGLN2JAK2JAK1NUDT1DYRK3 | |
| SCHEMBL258972 | 0.70 | EGLN2 (0.50) | EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889673-B2 | Triazolopyridine JAK inhibitor compounds and methods | GENENTECH, INC. (US) | 2014-11-18 | — | — | US | disclosed |