Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25800414 | 0.86 | MAPT (0.59) | PDK2MAPTMEN1NPC1HTT | |
| SCHEMBL12139669 | 0.84 | PDK2 (0.46) | AKR1C3AKR1C2PDK2HDAC6HDAC4 | |
| SCHEMBL25800418 | 0.84 | RAB9A (0.63) | MAPTMEN1NPC1HTTRAB9A | |
| SCHEMBL16255738 | 0.84 | AKR1C3 (0.60) | AKR1C3AKR1C2ALDH1A1PDE3BPDE3A | |
| SCHEMBL16255742 | 0.83 | TDP1 (0.53) | AKR1C3AKR1C2PDK2MAPTNPC1 | |
| SCHEMBL7920742 | 0.82 | AKR1C3 (0.53) | AKR1C3AKR1C2PDK2KDM1APDE3B | |
| SCHEMBL12142108 | 0.82 | PLK1 (0.56) | AKR1C3AKR1C2PDK2HDAC6HDAC4 | |
| SCHEMBL16255765 | 0.82 | TERT (0.48) | AKR1C3AKR1C2MMP13MEN1NPC1 | |
| SCHEMBL28192342 | 0.81 | PLK1 (0.57) | AKR1C3AKR1C2PDK2ALDH1A1PLK1 | |
| SCHEMBL22304413 | 0.81 | AKR1C3 (0.55) | AKR1C3AKR1C2PDE3BPDE3AS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889706-B2 | Soluble mTOR complexes and modulators thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2014-11-18 | — | — | US | disclosed |