Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | POLA1 | P09884 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16257566 | 0.82 | MEN1 (0.42) | SMN1; SMN2TP53MAPTCCR2CCR5 | |
| SCHEMBL15083664 | 0.78 | CCR2 (0.43) | RAPGEF4SMN1; SMN2TP53MAPTCCR2 | |
| SCHEMBL15033797 | 0.76 | MAPT (0.49) | RAPGEF4SMN1; SMN2TP53MAPTNPY5R | |
| SCHEMBL2743307 | 0.69 | PDE10A (0.39) | KDM4EALDH1A1 | |
| SCHEMBL20539053 | 0.67 | DHODH (0.68) | DHODHALOX15HSD17B10 | |
| SCHEMBL15119854 | 0.67 | NPC1 (0.41) | SMN1; SMN2MAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL10956452 | 0.66 | ERBB2 (0.55) | RAPGEF4SMN1; SMN2TP53GRM4NPC1 | |
| SCHEMBL15033751 | 0.66 | KMO (0.45) | RAPGEF4SMN1; SMN2MAPTKDM4ENPY5R | |
| SCHEMBL24754871 | 0.65 | MAPT (0.49) | SMN1; SMN2TP53MAPTCCR2CCR5 | |
| SCHEMBL15033703 | 0.65 | MAPT (0.63) | RAPGEF4SMN1; SMN2TP53MAPTCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946218-B2 | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| EP-2569295-B1 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |