Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | CCR2 | P41597 | 2/20 | 0.37 |
| ▸ | CCR5 | P51681 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15033751 | 0.84 | KMO (0.45) | MEN1KMT2AKMOSMN1; SMN2MAPT | |
| SCHEMBL16257510 | 0.82 | RAPGEF4 (0.41) | SMN1; SMN2MAPTDHODHNPSR1KDM4E | |
| SCHEMBL15083655 | 0.81 | CCR2 (0.51) | MEN1KMT2AKMOSMN1; SMN2MAPT | |
| SCHEMBL15033718 | 0.80 | MAPT (0.43) | MEN1KMT2AKMOSMN1; SMN2MAPT | |
| SCHEMBL15033697 | 0.78 | ADORA3 (0.42) | MEN1KMT2AKMOSMN1; SMN2MAPT | |
| SCHEMBL15033668 | 0.76 | KMO (0.58) | MEN1KMT2AKMOSMN1; SMN2HTT | |
| SCHEMBL16257557 | 0.76 | CCR2 (0.60) | CCR2CCR5EPHX2 | |
| SCHEMBL18924957 | 0.73 | PDE4A (0.38) | MEN1KMT2AL3MBTL1MAPTCDK2 | |
| SCHEMBL16257590 | 0.73 | KIT (0.50) | KMODHODHCSNK2A1 | |
| SCHEMBL15119870 | 0.71 | PTPRC (0.42) | MEN1KMT2AKMOHTTCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946218-B2 | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| EP-2569295-B1 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |