Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16257512 | 0.89 | EGFR (0.48) | DHODHLMNAPOLBMAPTSMN1; SMN2 | |
| SCHEMBL16257608 | 0.89 | HPGD (0.47) | DHODHLMNAPOLBMAPTSMN1; SMN2 | |
| SCHEMBL16257591 | 0.89 | EGFR (0.50) | DHODHLMNAPOLBMAPTSMN1; SMN2 | |
| SCHEMBL16257589 | 0.84 | CSNK2A2 (0.48) | DHODHLMNAPOLBMAPTSMN1; SMN2 | |
| SCHEMBL16257575 | 0.84 | MAPT (0.48) | LMNAPOLBMAPTSMN1; SMN2RAB9A | |
| SCHEMBL14318457 | 0.79 | TP53 (0.65) | DHODHLMNAPOLBMAPTSMN1; SMN2 | |
| SCHEMBL12179967 | 0.77 | DHODH (0.52) | DHODHLMNABRAFKDR | |
| SCHEMBL2627315 | 0.75 | SYK (0.60) | DHODHLMNAMAPTSMN1; SMN2RAB9A | |
| SCHEMBL16257513 | 0.74 | CSF1R (0.45) | MAPTRAB9AKDM4EALDH1A1KDR | |
| SCHEMBL16257609 | 0.74 | CSF1R (0.47) | MAPTRAB9AKDM4EALDH1A1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946218-B2 | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| EP-2569295-B1 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |