Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | CDC25B | P30305 | 4/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CDC25A | P30304 | 1/20 | 0.43 |
| ▸ | CDC25C | P30307 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16257576 | 0.87 | ANO1 (0.49) | KDREGFRABCG2ANO1ANO2 | |
| SCHEMBL16257511 | 0.84 | DHODH (0.55) | MAPTSMN1; SMN2LMNAPOLBRAB9A | |
| SCHEMBL16257591 | 0.80 | EGFR (0.50) | MAPTSMN1; SMN2LMNAPOLBRAB9A | |
| SCHEMBL16257512 | 0.78 | EGFR (0.48) | MAPTSMN1; SMN2LMNAPOLBSHMT2 | |
| SCHEMBL16257608 | 0.75 | HPGD (0.47) | MAPTSMN1; SMN2LMNAPOLBRAB9A | |
| SCHEMBL14318457 | 0.72 | TP53 (0.65) | MAPTSMN1; SMN2LMNAPOLBMEN1 | |
| SCHEMBL12179967 | 0.69 | DHODH (0.52) | LMNAKDRTP53 | |
| SCHEMBL16257589 | 0.68 | CSNK2A2 (0.48) | MAPTSMN1; SMN2LMNAPOLBRAB9A | |
| SCHEMBL16505479 | 0.67 | KDM4E (0.56) | MAPTSMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL6662871 | 0.67 | KDR (0.77) | RAB9AKDREGFRKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946218-B2 | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| EP-2569295-B1 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |