Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16257514 | 0.87 | KDM4E (0.46) | FYNSRCMAPK1EGFRKDM4E | |
| SCHEMBL16257513 | 0.87 | CSF1R (0.45) | NPC1RAB9AMAPTMAPK1ALDH1A1 | |
| SCHEMBL16257609 | 0.86 | CSF1R (0.47) | NPC1RAB9AMAPTMAPK1ALDH1A1 | |
| SCHEMBL16257511 | 0.84 | DHODH (0.55) | CSNK2A2CSNK2A1FYNSRCNPC1 | |
| SCHEMBL16257576 | 0.81 | ANO1 (0.49) | IGF1REGFR | |
| SCHEMBL15033668 | 0.80 | KMO (0.58) | NPC1RAB9AHSD17B10EGFRGRM4 | |
| SCHEMBL16257563 | 0.76 | ALDH1A1 (0.38) | CSNK2A2CSNK2A1MAPTMAPK1ALDH1A1 | |
| SCHEMBL14306362 | 0.76 | LMNA (0.58) | CSNK2A2CSNK2A1DHODHALDH1A1CYP3A4 | |
| SCHEMBL16257590 | 0.74 | KIT (0.50) | CSNK2A1DHODHGRM4 | |
| SCHEMBL16257512 | 0.73 | EGFR (0.48) | CSNK2A2CSNK2A1MAPTDHODHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946218-B2 | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| EP-2569295-B1 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |