Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.42 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16257591 | 0.98 | EGFR (0.50) | EGFRERBB3DHODHMAPTKDM4E | |
| SCHEMBL16257511 | 0.89 | DHODH (0.55) | EGFRERBB3DHODHMAPTKDM4E | |
| SCHEMBL16257513 | 0.87 | CSF1R (0.45) | EGFRERBB3MAPTKDM4ENPSR1 | |
| SCHEMBL16257608 | 0.85 | HPGD (0.47) | EGFRDHODHMAPTKDM4ETP53 | |
| SCHEMBL16257609 | 0.84 | CSF1R (0.47) | EGFRERBB3MAPTKDM4ENPSR1 | |
| SCHEMBL12180012 | 0.78 | CCR2 (0.48) | ALDH1A1HPGDPOLB | |
| SCHEMBL16257575 | 0.78 | MAPT (0.48) | EGFRMAPTKDM4ETP53SMN1; SMN2 | |
| SCHEMBL12180017 | 0.76 | CCR2 (0.49) | ALDH1A1HPGDMEN1KMT2APOLB | |
| SCHEMBL12179967 | 0.74 | DHODH (0.52) | DHODHTP53LMNA | |
| SCHEMBL16257589 | 0.73 | CSNK2A2 (0.48) | EGFRDHODHMAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946218-B2 | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| EP-2569295-B1 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |