Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 6/20 | 0.48 |
| ▸ | CCR5 | P51681 | 4/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | UBE2M | P61081 | 1/20 | 0.43 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | IDH2 | P48735 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16257550 | 0.90 | CCR2 (0.52) | CCR2CCR5CNR2UBE2MDCUN1D1 | |
| SCHEMBL16257553 | 0.90 | CCR2 (0.62) | CCR2CCR5KCNH2 | |
| SCHEMBL16257560 | 0.90 | CCR2 (0.62) | CCR2CCR5KCNH2 | |
| SCHEMBL16257554 | 0.84 | CCR2 (0.63) | CCR2CCR5EPHX2EGFROPRK1 | |
| SCHEMBL15033680 | 0.83 | CCR2 (0.40) | CCR2CCR5CNR2UBE2MDCUN1D1 | |
| SCHEMBL15033671 | 0.83 | CCR2 (0.40) | CCR2CCR5CNR2UBE2MDCUN1D1 | |
| SCHEMBL16257526 | 0.80 | CCR2 (0.61) | CCR2CCR5KCNH2 | |
| SCHEMBL16257552 | 0.80 | CCR2 (0.61) | CCR2CCR5KCNH2 | |
| SCHEMBL16257524 | 0.79 | CCR2 (0.61) | CCR2CCR5CNR2EPHX2 | |
| SCHEMBL16257556 | 0.79 | CCR2 (0.61) | CCR2CCR5CNR2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946218-B2 | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| EP-2569295-B1 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |