Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.63 |
| ▸ | CCR5 | P51681 | 1/20 | 0.63 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 3/20 | 0.38 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16257572 | 0.89 | CCR2 (0.69) | CCR2CCR5EPHA2KDREPHB4 | |
| SCHEMBL16257523 | 0.89 | CCR2 (0.80) | CCR2CCR5EPHA2KDREPHB4 | |
| SCHEMBL16257522 | 0.89 | CCR2 (0.80) | CCR2CCR5EPHA2KDREPHB4 | |
| SCHEMBL16257561 | 0.86 | CCR2 (0.78) | CCR2CCR5EPHA2KDREPHB4 | |
| SCHEMBL16257557 | 0.86 | CCR2 (0.60) | CCR2CCR5EPHA2KDREPHB4 | |
| SCHEMBL16257525 | 0.84 | CCR2 (0.48) | CCR2CCR5EGFROPRK1EPHX2 | |
| SCHEMBL15033674 | 0.81 | CCR2 (0.53) | CCR2CCR5EPHA2KDREPHB4 | |
| SCHEMBL15033672 | 0.81 | CCR2 (0.53) | CCR2CCR5EPHA2KDREPHB4 | |
| SCHEMBL12179993 | 0.79 | CCR2 (0.79) | CCR2CCR5LRRK2 | |
| SCHEMBL12180006 | 0.79 | CCR2 (0.79) | CCR2CCR5LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946218-B2 | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| EP-2569295-B1 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |