Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 6/20 | 0.60 |
| ▸ | CCR5 | P51681 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | RHOC | P08134 | 1/20 | 0.36 |
| ▸ | RHOA | P61586 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16257521 | 0.88 | CCR2 (0.80) | CCR2CCR5 | |
| SCHEMBL16257573 | 0.88 | CCR2 (0.80) | CCR2CCR5 | |
| SCHEMBL16257554 | 0.86 | CCR2 (0.63) | CCR2CCR5TYRO3LRRK2AXL | |
| SCHEMBL16257561 | 0.84 | CCR2 (0.78) | CCR2CCR5MKNK2EPHA2KDR | |
| SCHEMBL16257528 | 0.78 | CCR2 (0.66) | CCR2CCR5CNR2TYRO3EPHX2 | |
| SCHEMBL12180013 | 0.78 | CCR2 (0.66) | CCR2CCR5CNR2TYRO3EPHX2 | |
| SCHEMBL15083660 | 0.77 | CCR2 (0.83) | CCR2CCR5EPHX2EPHA2KDR | |
| SCHEMBL15083656 | 0.77 | CCR2 (0.83) | CCR2CCR5EPHX2EPHA2KDR | |
| SCHEMBL16257572 | 0.77 | CCR2 (0.69) | CCR2CCR5TYRO3LRRK2AXL | |
| SCHEMBL16257525 | 0.76 | CCR2 (0.48) | CCR2CCR5CNR2BRAFEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946218-B2 | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| EP-2569295-B1 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |