Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.72 |
| ▸ | HTR2B | P41595 | 1/20 | 0.72 |
| ▸ | AR | P10275 | 7/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diflucortolone 21-Valerate SCHEMBL3015 | 0.99 | PGR (0.73) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL13157 | 0.99 | PGR (0.73) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL13158 | 0.99 | PGR (0.73) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL9388448 | 0.99 | PGR (0.73) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL11243011 | 0.99 | PGR (0.73) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL2790985 | 0.99 | PGR (0.73) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL1021717 | 0.99 | PGR (0.73) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL18113135 | 0.98 | PGR (0.72) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL2353254 | 0.98 | PGR (0.72) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL15312089 | 0.98 | PGR (0.72) | PGRNR1I2HTR2BARHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3119394-B1 | COMPOSITIONS AND METHODS COMPRISING 2-(ACYLAMINO)IMIDAZOLES | CURZA GLOBAL LLC (US) | 2021-05-12 | — | — | EP | disclosed |
| US-10493061-B2 | Compositions and methods comprising 2-(acylamino)imidazoles | CURZA GLOBAL, LLC (US) | 2019-12-03 | — | — | US | disclosed |
| US-20190209716-A1 | PET IMAGING OF ZINC TRANSPORT | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2019-07-11 | — | — | US | disclosed |
| US-10279054-B2 | Pet imaging of zinc transport | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2019-05-07 | — | — | US | disclosed |
| US-20170100375-A1 | COMPOSITIONS AND METHODS COMPRISING 2-(ACYLAMINO)IMIDAZOLES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-04-13 | — | — | US | disclosed |
| EP-3119394-A2 | COMPOSITIONS AND METHODS COMPRISING 2-(ACYLAMINO)IMIDAZOLES | Curza Global LLC (US) | 2017-01-25 | — | — | EP | disclosed |
| US-20160175465-A1 | PET IMAGING OF ZINC TRANSPORT | UNITED STATES DEPARTMENT OF ENERGY | 2016-06-23 | — | — | US | disclosed |
| US-20160115543-A1 | Neurosurgical Genomics | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-04-28 | — | — | US | disclosed |
| WO-2015143240-A2 | COMPOSITIONS AND METHODS COMPRISING 2-(ACYLAMINO)IMIDAZOLES | CURZA GLOBAL, LLC (US) | 2015-09-24 | — | — | WO | disclosed |
| WO-2015006453-A2 | PET IMAGING OF ZINC TRANSPORT | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2015-01-15 | — | — | WO | disclosed |
| WO-2014194108-A1 | NEUROSURGICAL GENOMICS | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2014-12-04 | — | — | WO | disclosed |
| WO-2012027794-A2 | METHOD OF TREATMENT AND AGENTS USEFUL FOR SAME | THE MENTAL HEALTH RESEARCH INSTITUTE OF VICTORIA (AU) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10493061-B2 | Compositions and methods comprising 2-(acylamino)imidazoles | AADAC, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HDAC6 | PGR 3868/4885NR1I2 3782/4885HTR2B 2172/4885 |
| US-20170100375-A1 | COMPOSITIONS AND METHODS COMPRISING 2-(ACYLAMINO)IMIDAZOLES | AADAC, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HDAC6 | PGR 3868/4885NR1I2 3782/4885HTR2B 2172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.