Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Diflucortolone 21-Valerate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.72 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 3/20 | 0.62 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.52 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 8/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.72 |
| ▸ | AR | P10275 | 7/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diflucortolone 21-Valerate SCHEMBL11243011 | 0.99 | PGR (0.73) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL1021717 | 0.99 | PGR (0.73) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL3015 | 0.99 | PGR (0.73) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL9388448 | 0.99 | PGR (0.73) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL13158 | 0.99 | PGR (0.73) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL2790985 | 0.99 | PGR (0.73) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL13157 | 0.99 | PGR (0.73) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL162594 | 0.98 | PGR (0.72) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL4454848 | 0.98 | PGR (0.72) | PGRNR1I2HTR2BARHIF1A | |
| Diflucortolone 21-Valerate SCHEMBL20571795 | 0.98 | PGR (0.72) | PGRNR1I2HTR2BARHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107880-A1 | Spinal intervertebral implant, interconnections for such implant and processes for making | OSTEOTECH, INC. | 2005-05-19 | — | — | US | claimed |
| EP-1450736-A2 | SPINAL INTERVERTEBRAL IMPLANT, INTERCONNECTIONS FOR SUCH IMPLANT AND PROCESSES FOR MAKING | Osteotech, Inc. (US) | 2004-09-01 | — | — | EP | claimed |
| WO-2003047473-A2 | SPINAL INTERVERTEBRAL IMPLANT, INTERCONNECTIONS FOR SUCH IMPLANT AND PROCESSES FOR MAKING | OSTEOTECH, INC. (US) | 2003-06-12 | — | — | WO | claimed |
| US-20030105528-A1 | Spinal intervertebral implant, interconnections for such implant and processes for making | OSTEOTECH, INC. | 2003-06-05 | — | — | US | claimed |
| US-20120150222-A1 | Apparatus and method for anchoring sutures | BARTLETT EDWIN C (US) | 2012-06-14 | — | — | US | disclosed |
| US-8021390-B2 | Apparatus and method for anchoring sutures | BARTLETT EDWIN C | 2011-09-20 | — | — | US | disclosed |
| US-7998171-B2 | Apparatus and method for anchoring sutures | DEPUY MITEK, INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100217318-A9 | APPARATUS AND METHOD FOR ANCHORING SUTURES | BARTLETT EDWIN C | 2010-08-26 | — | — | US | disclosed |
| US-7726002-B2 | Processes for making spinal intervertebral implant, interconnections for such implant | OSTEOTECH, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-20070162074-A1 | Apparatus and method for anchoring sutures | BARTLETT EDWIN C | 2007-07-12 | — | — | US | disclosed |
| US-7217280-B2 | Apparatus and method for anchoring sutures | BARTLETT EDWIN C | 2007-05-15 | — | — | US | disclosed |
| US-20060036283-A1 | Apparatus and method for anchoring sutures | BARTLETT EDWIN C | 2006-02-16 | — | — | US | disclosed |
| US-20040181257-A1 | Apparatus and method for anchoring sutures | BARTLETT EDWIN C (US) | 2004-09-16 | — | — | US | disclosed |
| US-6749620-B2 | Apparatus and method for anchoring sutures | BARTLETT EDWIN C (US) | 2004-06-15 | — | — | US | disclosed |
| US-20020099411-A1 | Apparatus and method for anchoring sutures | BARTLETT EDWIN C (US) | 2002-07-25 | — | — | US | disclosed |
| US-6146408-A | Apparatus and method for anchoring sutures | BARTLETT EDWIN C (US) | 2000-11-14 | — | — | US | disclosed |
| US-5879372-A | Apparatus and method for anchoring sutures | BARTLETT EDWIN C (US) | 1999-03-09 | — | — | US | disclosed |
| US-5626612-A | Apparatus and method for anchoring sutures | GENERAL HOSPITAL CORPORATION, THE | 1997-05-06 | — | — | US | disclosed |
| EP-0670697-A1 | APPARATUS AND METHOD FOR ANCHORING SUTURES | Bartlett, Edwin C. (US) | 1995-09-13 | — | — | EP | disclosed |
| WO-1995008295-A2 | APPARATUS AND METHOD FOR ANCHORING SUTURES | BARTLETT EDWIN C (US) | 1995-03-30 | — | — | WO | disclosed |