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Sugi Predict / Compounds / Diflucortolone 21-Valerate

Diflucortolone 21-Valerate

Diflucortolone 21-Valerate

SCHEMBL1021717

CCCCC(=O)OCC(=O)[C@H]1[C@H](C)CC2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ PGR P06401 8/20 0.73
▸ NR1I2 O75469 3/20 0.73
▸ HTR2B P41595 1/20 0.73
▸ HIF1A Q16665 7/20 0.63
▸ AR P10275 7/20 0.63
▸ CYP3A4 P08684 5/20 0.63
▸ ADORA3 P0DMS8 3/20 0.63
▸ LMNA P02545 2/20 0.55
▸ NPSR1 Q6W5P4 1/20 0.55
▸ NR3C1 P04150 9/20 0.53
▸ SMN1; SMN2 Q16637 3/20 0.53
▸ ALDH1A1 P00352 2/20 0.53
▸ CYP1A2 P05177 1/20 0.53
▸ NR3C2 P08235 1/20 0.53
▸ CHRM1 P11229 2/20 0.53
▸ ABCB11 O95342 2/20 0.53
▸ ADRA1A P35348 1/20 0.52
▸ MAPT P10636 1/20 0.52
▸ RAB9A P51151 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Diflucortolone 21-Valerate SCHEMBL2790985 1.00 PGR (0.73) PGRNR1I2HTR2BHIF1AAR
Diflucortolone 21-Valerate SCHEMBL3015 1.00 PGR (0.73) PGRNR1I2HTR2BHIF1AAR
Diflucortolone 21-Valerate SCHEMBL11243011 1.00 PGR (0.73) PGRNR1I2HTR2BHIF1AAR
Diflucortolone 21-Valerate SCHEMBL9388448 1.00 PGR (0.73) PGRNR1I2HTR2BHIF1AAR
Diflucortolone 21-Valerate SCHEMBL13158 1.00 PGR (0.73) PGRNR1I2HTR2BHIF1AAR
Diflucortolone 21-Valerate SCHEMBL13157 1.00 PGR (0.73) PGRNR1I2HTR2BHIF1AAR
Diflucortolone 21-Valerate SCHEMBL18113135 0.99 PGR (0.72) PGRNR1I2HTR2BHIF1AAR
Diflucortolone 21-Valerate SCHEMBL2353254 0.99 PGR (0.72) PGRNR1I2HTR2BHIF1AAR
Diflucortolone 21-Valerate SCHEMBL4454848 0.99 PGR (0.72) PGRNR1I2HTR2BHIF1AAR
Diflucortolone 21-Valerate SCHEMBL20571795 0.99 PGR (0.72) PGRNR1I2HTR2BHIF1AAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1951200-A2 NANOEMULSION COMPOSITIONS HAVING ANTI-INFLAMMATORY ACTIVITY Nanobio Corporation (US) 2008-08-06 — — EP claimed
WO-2008051186-A2 NANOEMULSION CONTAINING COMPOSITIONS HAVING ANT I -INFLAMMATORY ACTIVITY NANOBIO CORPORATION (US) 2008-05-02 — — WO claimed
US-20070036831-A1 Nanoemulsion compositions having anti-inflammatory activity NANOBIO CORPORATION 2007-02-15 — — US claimed
US-11160764-B2 Drug delivery composition containing silyl polymers MEDHERANT LIMITED (GB) 2021-11-02 — — US disclosed
CN-111249221-A Diflucolone cream ester and preparation method thereof 天津金耀药业有限公司 2020-06-09 — — CN disclosed
US-20190145967-A1 INDEX OF LOCAL SEVERITY OF ATOPIC DERMATITIS IN SKIN AND THERAPEUTIC EFFECT THEREON SHISEIDO COMPANY. LTD. (JP) 2019-05-16 — — US disclosed
US-20180318233-A1 DRUG DELIVERY COMPOSITION CONTAINING SILYL POLYMERS MEDHERANT LIMITED (GB) 2018-11-08 — — US disclosed
WO-2018203048-A1 DRUG DELIVERY COMPOSITION MEDHERANT LIMITED (GB) 2018-11-08 — — WO disclosed
EP-3370696-A1 DRUG DELIVERY COMPOSITION CONTAINING SILYL POLYMERS Medherant Limited (GB) 2018-09-12 — — EP disclosed
CN-108289831-A Drug delivery compositions containing silyl polymers 海伦特医药有限公司 2018-07-17 — — CN disclosed
EP-1912624-B1 ANHYDROUS MULTIPHASE GEL SYSTEM INTENDIS GMBH (DE) 2017-07-19 — — EP disclosed
EP-0230942-A2 Thieno-1,4-diazepines BOEHRINGER INGELHEIM KG (DE) 1987-08-05 — — EP disclosed
EP-0110041-B1 6-ALPHA-METHYL-CORTICOIDS, THEIR PREPARATION AND UTILIZATION SCHERING AKTIENGESELLSCHAFT (DE) 1987-07-29 — — EP disclosed
US-4645763-A 6α-methyl corticoids, their production and use SCHERING AKTIENGESELLSCHAFT (DE) 1987-02-24 — — US disclosed
EP-0072547-B1 6-ALPHA-METHYL-PREDNISOLONE DERIVATIVES, THEIR PREPARATION AND UTILIZATION SCHERING AKTIENGESELLSCHAFT (DE) 1986-03-26 — — EP disclosed
EP-0144086-A2 Hydrocortisone and prednisolone derivatives SCHERING AKTIENGESELLSCHAFT (DE) 1985-06-12 — — EP disclosed
EP-0054786-B1 6-ALPHA-METHYL HYDROCORTISONE DERIVATIVES, THEIR PREPARATION AND THEIR UTILIZATION SCHERING AKTIENGESELLSCHAFT (DE) 1985-03-20 — — EP disclosed
EP-0110041-A1 6-Alpha-methyl-corticoids, their preparation and utilization SCHERING AKTIENGESELLSCHAFT (DE) 1984-06-13 — — EP disclosed
EP-0072547-A1 6-Alpha-methyl-prednisolone derivatives, their preparation and utilization SCHERING AKTIENGESELLSCHAFT (DE) 1983-02-23 — — EP disclosed
EP-0054786-A1 6-Alpha-methyl hydrocortisone derivatives, their preparation and their utilization SCHERING AKTIENGESELLSCHAFT (DE) 1982-06-30 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11160764-B2 Drug delivery composition containing silyl polymers ILK, ITGAL, LCP1 PGR 722/4885NR1I2 737/4885HTR2B 1793/4885
US-20180318233-A1 DRUG DELIVERY COMPOSITION CONTAINING SILYL POLYMERS ILK, ITGAL, LCP1 PGR 722/4885NR1I2 737/4885HTR2B 1793/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.