Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | ECE1 | P42892 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.33 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814755 | 0.91 | L3MBTL1 (0.35) | MMP12ECE1LMNATDP1ALDH1A1 | |
| SCHEMBL3692336 | 0.88 | MMP12 (0.47) | MMP12LMNASMN1; SMN2SLC22A6GABRR1 | |
| Hydrochloric Acid SCHEMBL3698117 | 0.85 | MMP12 (0.46) | MMP12LMNASMN1; SMN2PARP1PARP10 | |
| SCHEMBL6540754 | 0.81 | — | — | |
| SCHEMBL13597717 | 0.79 | LMNA (0.42) | MMP12LMNASMN1; SMN2SLC22A6TDP1 | |
| SCHEMBL1618297 | 0.79 | — | — | |
| SCHEMBL12787257 | 0.79 | LMNA (0.42) | MMP12LMNASMN1; SMN2SLC22A6TDP1 | |
| SCHEMBL14633169 | 0.77 | L3MBTL1 (0.32) | ALDH1A1 | |
| SCHEMBL15382406 | 0.77 | TSHR (0.41) | MMP12LMNASMN1; SMN2SLC22A6TDP1 | |
| SCHEMBL3193802 | 0.77 | TSHR (0.41) | MMP12LMNASMN1; SMN2SLC22A6TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273333-B2 | Process for the preparation of intermediates of HMG-CoA reductase inhibitors | MYLAN LABORATORIES LTD (IN) | 2016-03-01 | — | — | US | disclosed |
| US-20140349350-A1 | Novel Process for the Preparation of Intermediates of HMG-CoA Reductase Inhibitors | TIANISH LABORATORIES PRIVATE LIMITED (IN) | 2014-11-27 | — | — | US | disclosed |