Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.36 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5922605 | 0.99 | HTR6 (0.41) | HTR6PRMT5WDR77DRD3LMNA | |
| SCHEMBL1626463 | 0.89 | PRMT5 (0.43) | HTR6PRMT5WDR77LMNAHTT | |
| Hydrochloric Acid SCHEMBL5922613 | 0.88 | PRMT5 (0.42) | HTR6PRMT5WDR77LMNAHTT | |
| Hydrochloric Acid SCHEMBL14237064 | 0.86 | MEN1 (0.43) | HTR6DRD3LMNAAKR1C3MEN1 | |
| SCHEMBL14236984 | 0.78 | HTR6 (0.42) | HTR6DRD3LMNAMEN1KMT2A | |
| SCHEMBL14237121 | 0.78 | MAPT (0.43) | HTR6DRD3LMNAHTTMEN1 | |
| SCHEMBL14237108 | 0.78 | MEN1 (0.53) | LMNAHTTMEN1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1627341 | 0.78 | HTR6 (0.41) | HTR6DRD3LMNAMEN1KMT2A | |
| SCHEMBL14236969 | 0.77 | SMN1; SMN2 (0.43) | HTR6LMNAHTTSMN1; SMN2TSHR | |
| Hydrochloric Acid SCHEMBL1625092 | 0.77 | MAPT (0.42) | HTR6DRD3LMNAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831195-B1 | 5-HT7 RECEPTOR ANTAGONISTS | ESTEVE LABOR DR (ES) | 2012-12-19 | — | — | EP | claimed |
| US-7928121-B2 | 2-[1-(5-Chloro-2,4-difluoro-benzenesulfonyl)-piperidin-4-ylmethyl]-1,2,3,4-tetrahydroisoquinolinehydrochloride; antidepressant, anxiolytic, hypotensive agent; psychosis, schizophrenia, migraine, cognition activity; pharmacokinetics | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-04-19 | — | — | US | disclosed |