Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.34 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5922613 | 0.99 | PRMT5 (0.42) | PRMT5LMNAHTTAKR1C3DPP8 | |
| SCHEMBL1626459 | 0.89 | HTR6 (0.42) | PRMT5LMNAHTTAKR1C3DPP8 | |
| SCHEMBL14236989 | 0.89 | MCOLN2 (0.41) | PRMT5LMNADPP8HTR6MEN1 | |
| Hydrochloric Acid SCHEMBL5922605 | 0.88 | HTR6 (0.41) | PRMT5LMNAHTTAKR1C3DPP8 | |
| Hydrochloric Acid SCHEMBL1626825 | 0.88 | MCOLN2 (0.40) | PRMT5LMNADPP8HTR6MEN1 | |
| SCHEMBL14237117 | 0.81 | HTR6 (0.40) | PRMT5LMNAHTR6MEN1KMT2A | |
| SCHEMBL1629614 | 0.80 | MEN1 (0.50) | LMNAHTTHTR6MEN1KMT2A | |
| SCHEMBL14237015 | 0.80 | MAPT (0.41) | PRMT5LMNAHTTHTR6MEN1 | |
| SCHEMBL14237044 | 0.80 | PKM (0.38) | LMNAMEN1KMT2A | |
| SCHEMBL1625414 | 0.80 | SMN1; SMN2 (0.43) | LMNAHTTHTR6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831195-B1 | 5-HT7 RECEPTOR ANTAGONISTS | ESTEVE LABOR DR (ES) | 2012-12-19 | — | — | EP | claimed |
| EP-1831195-B1 | 5-HT7 RECEPTOR ANTAGONISTS | ESTEVE LABOR DR (ES) | 2012-12-19 | — | — | EP | disclosed |
| US-7928121-B2 | 2-[1-(5-Chloro-2,4-difluoro-benzenesulfonyl)-piperidin-4-ylmethyl]-1,2,3,4-tetrahydroisoquinolinehydrochloride; antidepressant, anxiolytic, hypotensive agent; psychosis, schizophrenia, migraine, cognition activity; pharmacokinetics | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-04-19 | — | — | US | disclosed |