Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 1/20 | 0.46 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.39 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16263155 | 0.85 | CCNE1 (0.37) | CCNKCDK12CCNE1CDK2MEN1 | |
| SCHEMBL18625817 | 0.84 | NAMPT (0.41) | CCNKCDK12CCNE1CDK2MEN1 | |
| SCHEMBL22321061 | 0.82 | CYP19A1 (0.59) | CCNKCDK12KDM5CKDM4CKDM2A | |
| SCHEMBL19723216 | 0.78 | CCNK (0.37) | CCNKCDK12KDM4EKDM5CKDM4C | |
| SCHEMBL22868021 | 0.74 | HDAC8 (0.53) | CCNKCDK12KDM4EKDM5CKDM4C | |
| SCHEMBL22868098 | 0.73 | EPHB4 (0.54) | CCNKCDK12KDM4EKDM5CKDM4C | |
| SCHEMBL16264705 | 0.72 | CCNK (0.44) | CCNKCDK12KDM4EKDM5CKDM4C | |
| SCHEMBL22868086 | 0.71 | HDAC3 (0.57) | CCNKCDK12MEN1KMT2AALDH1A1 | |
| Bromide SCHEMBL1887515 | 0.70 | CYP19A1 (0.64) | MEN1KMT2ACYP19A1NPC1RAB9A | |
| SCHEMBL22868177 | 0.70 | CA1 (0.48) | CCNKCDK12RETCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2999707-B1 | TYLOSIN DERIVATIVES AND METHOD FOR PREPARATION THEREOF | BAYER ANIMAL HEALTH GMBH (DE) | 2018-03-28 | — | — | EP | disclosed |
| EP-2782922-B1 | ANTIBACTERIAL TYLOSIN DERIVATIVES AND METHODS FOR THEIR PREPARATION | BAYER IP GMBH (DE) | 2017-12-20 | — | — | EP | disclosed |
| US-9771389-B2 | Tylosin derivatives and method for preparation thereof | THE KITASAKO INSTITUTE (JP) | 2017-09-26 | — | — | US | disclosed |
| US-9593140-B2 | Antibacterial tylosin derivatives and methods for their preparation | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-03-14 | — | — | US | disclosed |
| US-20160108077-A1 | TYLOSIN DERIVATIVES AND METHOD FOR PREPARATION THEREOF | THE KITASAKO INSTITUTE (JP) | 2016-04-21 | — | — | US | disclosed |
| US-20140349954-A1 | ANTIBACTERIAL TYLOSIN DERIVATIVES AND METHODS FOR THEIR PREPARATION | ELANCO ANIMAL HEALTH GMBH (DE) | 2014-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160108077-A1 | TYLOSIN DERIVATIVES AND METHOD FOR PREPARATION THEREOF | TMSB10, MLN, TMSB4X | CCNK 4301/4885CDK12 4353/4885KDM4E 3500/4885 |
| US-20140349954-A1 | ANTIBACTERIAL TYLOSIN DERIVATIVES AND METHODS FOR THEIR PREPARATION | MLN, TMSB10, TMSB4X | CCNK 4163/4885CDK12 4731/4885KDM4E 3469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.