Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16264766 | 0.84 | CCNK (0.46) | CCNE1CDK2MEN1KMT2ACYP11B1 | |
| SCHEMBL16263155 | 0.82 | CCNE1 (0.37) | CCNE1CDK2MEN1KMT2ATSHR | |
| SCHEMBL22321061 | 0.79 | CYP19A1 (0.59) | CDK2MEN1KMT2ACYP19A1NPC1 | |
| SCHEMBL20001350 | 0.75 | NAMPT (0.37) | NAMPTMGAMGAASIMGAM2 | |
| SCHEMBL18625821 | 0.74 | CYP19A1 (0.60) | NAMPTMGAMGAASIMGAM2 | |
| SCHEMBL13527780 | 0.74 | HTR2A (0.39) | NAMPTMGAMGAASIMGAM2 | |
| SCHEMBL18625959 | 0.72 | NAMPT (0.43) | NAMPTMGAMGAASIMGAM2 | |
| SCHEMBL18625968 | 0.72 | CYP19A1 (0.57) | NAMPTMGAMGAASIMGAM2 | |
| SCHEMBL24299431 | 0.69 | AAK1 (0.42) | NAMPTCCNKCDK12 | |
| SCHEMBL12304956 | 0.69 | TEK (0.55) | NAMPTMGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9771389-B2 | Tylosin derivatives and method for preparation thereof | THE KITASAKO INSTITUTE (JP) | 2017-09-26 | — | — | US | disclosed |
| US-9593140-B2 | Antibacterial tylosin derivatives and methods for their preparation | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-03-14 | — | — | US | disclosed |