Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.39 |
| ▸ | STK17B | O94768 | 2/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | BCL6 | P41182 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16264934 | 0.81 | RPS6KA3 (0.41) | MEN1KMT2AALDH1A1EGFRL3MBTL1 | |
| SCHEMBL16264830 | 0.79 | EGFR (0.45) | STK17ASTK17BKDM4EGAAEGFR | |
| SCHEMBL16264828 | 0.79 | EGFR (0.45) | STK17ASTK17BKDM4EGAAEGFR | |
| SCHEMBL16246107 | 0.78 | MEN1 (0.41) | MEN1KMT2APIN1HPGDRAB9A | |
| SCHEMBL16012862 | 0.78 | MEN1 (0.48) | MEN1KMT2ASTK17ASTK17BPIN1 | |
| SCHEMBL6507541 | 0.77 | ADORA3 (0.46) | MEN1KMT2ASTK17APIN1RAB9A | |
| SCHEMBL16264889 | 0.77 | STK17A (0.41) | MEN1KMT2ASTK17ASTK17BHPGD | |
| SCHEMBL16264851 | 0.75 | MEN1 (0.45) | MEN1KMT2APIN1RAB9AMAPT | |
| SCHEMBL15146279 | 0.75 | AURKA (0.47) | MEN1KMT2ASTK17ASTK17BPIN1 | |
| SCHEMBL2411693 | 0.75 | AURKA (0.53) | MEN1KMT2APIN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014180524-A1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2014-11-13 | — | — | WO | disclosed |