Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.41 |
| ▸ | STK17B | O94768 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16264828 | 0.88 | EGFR (0.45) | STK17ASTK17BSYKAURKAEGFR | |
| SCHEMBL16264830 | 0.88 | EGFR (0.45) | STK17ASTK17BSYKAURKAEGFR | |
| SCHEMBL16264934 | 0.78 | RPS6KA3 (0.41) | SYKMEN1KMT2AEGFRFGFR1 | |
| SCHEMBL16264901 | 0.77 | MEN1 (0.41) | STK17ASTK17BMEN1KMT2AEGFR | |
| SCHEMBL16245555 | 0.75 | P2RX3 (0.44) | SYKAURKAMAPTKDM4ENPC1 | |
| SCHEMBL16245559 | 0.73 | CYSLTR2 (0.44) | SYKAURKAMAPTKDM4ENPC1 | |
| SCHEMBL16264851 | 0.71 | MEN1 (0.45) | AURKAMEN1KMT2AEGFRMAPT | |
| SCHEMBL2411693 | 0.69 | AURKA (0.53) | SYKAURKAMEN1KMT2AEGFR | |
| SCHEMBL6507541 | 0.68 | ADORA3 (0.46) | STK17AMEN1KMT2AEGFRRAB9A | |
| SCHEMBL16264832 | 0.68 | STK17B (0.49) | STK17ASTK17BSYKHDAC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014180524-A1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2014-11-13 | — | — | WO | disclosed |