Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.53 |
| ▸ | TNK2 | Q07912 | 12/20 | 0.47 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.39 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | FECH | P22830 | 1/20 | 0.39 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.39 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL123385 | 0.89 | BTK (0.65) | BTKTNK2 | |
| SCHEMBL170106 | 0.88 | BTK (0.57) | BTKTNK2CSNK2A2PIK3CDACVRL1 | |
| SCHEMBL123306 | 0.88 | BTK (0.64) | BTKTNK2PIK3CDACVRL1 | |
| SCHEMBL169925 | 0.85 | BTK (0.50) | BTKTNK2CSNK2A2ACVRL1 | |
| SCHEMBL124143 | 0.84 | BTK (0.53) | BTKTNK2ACVRL1 | |
| SCHEMBL124142 | 0.84 | BTK (0.53) | BTKTNK2ACVRL1 | |
| SCHEMBL176919 | 0.80 | BTK (0.66) | BTKTNK2PIK3CDACVRL1 | |
| SCHEMBL122059 | 0.79 | BTK (0.83) | BTKTNK2RIPK2RETMAP2K5 | |
| SCHEMBL167469 | 0.79 | BTK (0.64) | BTKTNK2ACVRL1 | |
| SCHEMBL124181 | 0.78 | BTK (0.82) | BTKTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140357636-A1 | Treatment of Skeletal-Related Disorders | ROTHBAUM WAYNE (US) | 2014-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357636-A1 | Treatment of Skeletal-Related Disorders | SOST, COL2A1, CYP27B1 | BTK 4374/4885TNK2 1030/4885MTOR 3262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.