Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | PPID | Q08752 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14576313 | 0.88 | PPIB (0.56) | LMNASMN1; SMN2KMT2AMEN1HPGD | |
| SCHEMBL14617667 | 0.87 | SMN1; SMN2 (0.81) | LMNASMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL14900387 | 0.83 | KMT2A (0.71) | LMNASMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL17656854 | 0.80 | KMT2A (0.79) | LMNASMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL16270332 | 0.79 | MEN1 (0.61) | SMN1; SMN2KMT2AMEN1HTTHPGD | |
| SCHEMBL14617672 | 0.78 | SMN1; SMN2 (0.70) | SMN1; SMN2KMT2AMEN1HPGDNPC1 | |
| SCHEMBL13049648 | 0.78 | SMN1; SMN2 (1.00) | SMN1; SMN2KMT2AMEN1HPGDNPC1 | |
| SCHEMBL10133176 | 0.77 | NPC1 (0.67) | LMNASMN1; SMN2KMT2AMEN1HPGD | |
| SCHEMBL2036022 | 0.77 | LMNA (0.66) | LMNASMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL13652546 | 0.76 | LMNA (0.61) | LMNASMN1; SMN2KMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8901295-B2 | Inhibitors of cyclophilins and uses thereof | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2014-12-02 | — | — | US | disclosed |