Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | MMP13 | P45452 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12643953 | 0.89 | ALDH1A1 (0.60) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL3815151 | 0.84 | ALDH1A1 (0.72) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL14617667 | 0.83 | SMN1; SMN2 (0.81) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL2037882 | 0.80 | PPID (0.69) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL5334260 | 0.80 | MMP13 (0.85) | MEN1KMT2ASMN1; SMN2ALDH1A1MMP13 | |
| SCHEMBL16270336 | 0.79 | LMNA (0.67) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL13940425 | 0.78 | MMP13 (0.90) | SMN1; SMN2ALDH1A1HTTMMP13HPGD | |
| SCHEMBL16270320 | 0.78 | SMN1; SMN2 (0.52) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL934348 | 0.77 | ALDH1A1 (0.76) | SMN1; SMN2ALDH1A1HTTMMP13POLB | |
| SCHEMBL13853495 | 0.77 | ALDH1A1 (0.67) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8901295-B2 | Inhibitors of cyclophilins and uses thereof | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2014-12-02 | — | — | US | disclosed |