Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.47 |
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | MEN1 | O00255 | 9/20 | 0.47 |
| ▸ | NPC1 | O15118 | 8/20 | 0.47 |
| ▸ | RAB9A | P51151 | 8/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MMP14 | P50281 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL112231 | 0.92 | KMT2A (0.55) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL112230 | 0.92 | KMT2A (0.55) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL29358253 | 0.92 | KMT2A (0.55) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL10067503 | 0.87 | KMT2A (0.50) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL26605521 | 0.87 | ALDH1A1 (0.54) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL17787265 | 0.85 | MAPT (0.41) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL25419671 | 0.84 | KMT2A (0.47) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL12955663 | 0.84 | ALDH1A1 (0.42) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL7717321 | 0.84 | POLB (0.58) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL1087160 | 0.83 | MAPT (0.52) | KMT2AMAPTMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7927791-B2 | Methods for identifying small molecules that modulate premature translation termination and nonsense mediated mRNA decay | PTC THERAPEUTICS, INC. (US) | 2011-04-19 | — | — | US | disclosed |
| EP-2071036-A2 | Methods for identifying RNA-binding compounds | The University of Medicine and Dentistry of New Jersey (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1377684-A4 | METHODS FOR IDENTIFYING SMALL MOLECULES THAT BIND SPECIFIC RNA STRUCTURAL MOTIFS | PTC THERAPEUTICS INC (US) | 2009-03-18 | — | — | EP | disclosed |
| US-20060257866-A1 | Methods for identifying small molecules that modulate premature translation termination and nonsense mediated mrna decay | PTC THERAPEUTICS, INC. | 2006-11-16 | — | — | US | disclosed |
| EP-1543157-A4 | METHODS FOR IDENTIFYING SMALL MOLEDULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY | PTC THERAPEUTICS INC (US) | 2006-11-15 | — | — | EP | disclosed |
| US-20060228730-A1 | Methods for identifying small molecules that bind specific RNA structural motifs | RANDO ROBERT F | 2006-10-12 | — | — | US | disclosed |
| US-20060194234-A1 | Methods for identifying small molecules that bind specific RNA structural motifs | PTC THERAPEUTICS, INC. | 2006-08-31 | — | — | US | disclosed |
| US-20050221368-A1 | Methods for identifying RNA binding compounds | UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) | 2005-10-06 | — | — | US | disclosed |
| US-20050142545-A1 | Methods for identifying small molecules that bind specific rna structural motifs | PTC THERAPEUTICS, INC. | 2005-06-30 | — | — | US | disclosed |
| EP-1543157-A2 | METHODS FOR IDENTIFYING SMALL MOLEDULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY | PTC Therapeutics, Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| US-6875736-B2 | Methods for identifying RNA binding compounds | PTC THERAPEUTICS, INC. (US) | 2005-04-05 | — | — | US | disclosed |
| US-20040219545-A1 | Methods for identifying small molecules that bind specific rna structural motifs | RANDO ROBERT F (US) | 2004-11-04 | — | — | US | disclosed |
| WO-2004010106-A2 | METHODS FOR IDENTIFYING SMALL MOLEDULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY | PTC THERAPEUTICS, INC. (US) | 2004-01-29 | — | — | WO | disclosed |
| EP-1377684-A1 | METHODS FOR IDENTIFYING SMALL MOLECULES THAT BIND SPECIFIC RNA STRUCTURAL MOTIFS | PTC Therapeutics, Inc. (US) | 2004-01-07 | — | — | EP | disclosed |
| US-20030153523-A1 | Methods for identifying RNA binding compounds | UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY | 2003-08-14 | — | — | US | disclosed |
| US-6503713-B1 | Contacting an aqueous solution of a dye-labeled target RNA molecule with a plurality of test compounds attached to a plurality of solid supports, wherein each solid support has substantially one type of test compound attached to its | UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY | 2003-01-07 | — | — | US | disclosed |
| WO-2002083953-A1 | METHODS FOR IDENTIFYING SMALL MOLECULES THAT BIND SPECIFIC RNA STRUCTURAL MOTIFS | PTC THERAPEUTICS, INC. (US) | 2002-10-24 | — | — | WO | disclosed |
| WO-2002083837-A1 | METHODS FOR IDENTIFYING SMALL MOLECULES THAT BIND SPECIFIC RNA STRUCTURAL MOTIFS | PTC THERAPEUTICS, INC. (US) | 2002-10-24 | — | — | WO | disclosed |
| EP-1218544-A1 | METHODS FOR IDENTIFYING RNA BINDING COMPOUNDS | University of Medicine and Dentistry of New Jersey (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001025486-A1 | METHODS FOR IDENTIFYING RNA BINDING COMPOUNDS | UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) | 2001-04-12 | — | — | WO | disclosed |