SCHEMBL16280201

SCHEMBL16280201

Cc1cccc(-n2c3ccccc3c3ccc(Oc4cccc(-n5nc(C)cc5C)c4)cc32)n1.[Pt]

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.40
POLB P06746 2/20 0.40
RXFP1 Q9HBX9 1/20 0.40
MAPT P10636 6/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
ALDH1A1 P00352 4/20 0.37
ALOX15 P16050 2/20 0.36
NR1H2 P55055 1/20 0.34
NR1H3 Q13133 1/20 0.34
KDM4E B2RXH2 3/20 0.33
HPGD P15428 2/20 0.33
GAA P10253 2/20 0.33
TSHR P16473 2/20 0.33
ALOX12 P18054 1/20 0.33
HSD17B10 Q99714 1/20 0.33
DGAT2 Q96PD7 1/20 0.33
LMNA P02545 1/20 0.33
TDP1 Q9NUW8 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16279881 0.99 SMN1; SMN2 (0.41) SMN1; SMN2POLBRXFP1MAPTL3MBTL1
SCHEMBL16280425 0.89 SMN1; SMN2 (0.39) SMN1; SMN2POLBRXFP1MAPTL3MBTL1
SCHEMBL11969821 0.88 SMN1; SMN2 (0.40) SMN1; SMN2POLBRXFP1MAPTL3MBTL1
SCHEMBL16280565 0.87 SMN1; SMN2 (0.38) SMN1; SMN2POLBRXFP1MAPTL3MBTL1
SCHEMBL16280316 0.86 SMN1; SMN2 (0.39) SMN1; SMN2POLBRXFP1MAPTL3MBTL1
SCHEMBL16280428 0.85 SMN1; SMN2 (0.38) SMN1; SMN2POLBRXFP1MAPTL3MBTL1
SCHEMBL16280256 0.85 SMN1; SMN2 (0.38) SMN1; SMN2POLBRXFP1MAPTL3MBTL1
SCHEMBL16280370 0.84 SMN1; SMN2 (0.41) SMN1; SMN2POLBRXFP1MAPTL3MBTL1
SCHEMBL16280286 0.84 SMN1; SMN2 (0.39) SMN1; SMN2POLBRXFP1MAPTL3MBTL1
SCHEMBL16280194 0.84 SMN1; SMN2 (0.39) SMN1; SMN2POLBRXFP1MAPTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10211414-B2 Phosphorescent tetradentate metal complexes having modified emission spectra ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-02-19 US disclosed
US-9899614-B2 Phosphorescent tetradentate metal complexes having modified emission spectra ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2018-02-20 US disclosed
US-20170331056-A1 PHOSPHORESCENT TETRADENTATE METAL COMPLEXES HAVING MODIFIED EMISSION SPECTRA ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2017-11-16 US disclosed
US-9673409-B2 Phosphorescent tetradentate metal complexes having modified emission spectra ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2017-06-06 US disclosed
US-20160285015-A1 PHOSPHORESCENT TETRADENTATE METAL COMPLEXES HAVING MODIFIED EMISSION SPECTRA ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2016-09-29 US disclosed
WO-2015027060-A1 PHOSPHORESCENT TETRADENTATE METAL COMPLEXES HAVING MODIFIED EMISSION SPECTRA ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2015-02-26 WO disclosed
US-20140364605-A1 PHOSPHORESCENT TETRADENTATE METAL COMPLEXES HAVING MODIFIED EMISSION SPECTRA ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2014-12-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170331056-A1 PHOSPHORESCENT TETRADENTATE METAL COMPLEXES HAVING MODIFIED EMISSION SPECTRA AP2S1, PICALM, TRPC3 SMN1; SMN2 2678/4885POLB 2889/4885RXFP1 4793/4885
US-10211414-B2 Phosphorescent tetradentate metal complexes having modified emission spectra AP2S1, PICALM, TRPC3 SMN1; SMN2 2678/4885POLB 2889/4885RXFP1 4793/4885
US-20160285015-A1 PHOSPHORESCENT TETRADENTATE METAL COMPLEXES HAVING MODIFIED EMISSION SPECTRA OCIAD1, OCIAD2, OSGEP SMN1; SMN2 3880/4885POLB 1667/4885RXFP1 4799/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.