Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amiodarone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 1.00 |
| ▸ | SIRT3 | Q9NTG7 | 7/20 | 1.00 |
| ▸ | KDM5A | P29375 | 7/20 | 1.00 |
| ▸ | THRA | P10827 | 3/20 | 1.00 |
| ▸ | THRB | P10828 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 2/20 | 1.00 |
| ▸ | KDM7A | Q6ZMT4 | 2/20 | 1.00 |
| ▸ | MLNR | O43193 | 1/20 | 1.00 |
| ▸ | CACNA1F | O60840 | 1/20 | 1.00 |
| ▸ | PHF2 | O75151 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 1/20 | 1.00 |
| ▸ | ERBB2 | P04626 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | FYN | P06241 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amiodarone SCHEMBL5496372 | 1.00 | SIRT3 (1.00) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| Amiodarone SCHEMBL12487240 | 1.00 | SIRT3 (1.00) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| Amiodarone SCHEMBL29361787 | 1.00 | SIRT3 (1.00) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| Amiodarone SCHEMBL41348 | 0.99 | ALDH1A1 (1.00) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| Amiodarone SCHEMBL29362650 | 0.99 | ALDH1A1 (1.00) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| Amiodarone SCHEMBL29183902 | 0.99 | SIRT3 (0.98) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| Amiodarone SCHEMBL29173757 | 0.99 | SIRT3 (0.98) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| Amiodarone SCHEMBL28525007 | 0.99 | SIRT3 (0.98) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| Amiodarone SCHEMBL19809514 | 0.98 | SIRT3 (0.96) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| Amiodarone SCHEMBL28989964 | 0.98 | ALDH1A1 (0.98) | SIRT3KDM5ATHRATHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 32477 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| CN-117257677-B | Polymer nano micelle and preparation method and application thereof | GUANGDONG PHARMACEUTICAL UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| US-12629363-B2 | Prophylaxis and treatment of angioedema | PHARVARIS GMBH (CH) | 2026-05-19 | — | — | US | claimed |
| CN-122042833-A | Method for monitoring amiodarone blood concentration, monitoring preparation and application thereof | 中南民族大学 | 2026-05-15 | — | — | CN | claimed |
| WO-2026102345-A1 | METHODS OF ADMINISTERING THE VOLTAGE-GATED POTASSIUM CHANNEL OPENER AZETUKALNER | XENON PHARMACEUTICALS INC. (CA) | 2026-05-15 | — | — | WO | claimed |
| US-12617809-B2 | Cardioprotective lipid and method of use | SIGNPATH PHARMA, INC. (US) | 2026-05-05 | — | — | US | claimed |
| US-12609190-B2 | Method and equipment for improving cardiac arrest resuscitation (pocket crash cart) | FREEMAN TAMARA ALIZA (US) | 2026-04-21 | — | — | US | claimed |
| EP-4724062-A2 | COMPOSITIONS AND METHODS FOR INCREASING EXPOSURE OF R(-)-MDA | EmpathBio, Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| US-20260097100-A1 | CANCER TREATMENT BY INDUCTION OF TUMOR AND STEM CELL DIFFERENTIATION | LATHAM KEITH ROGER (US) | 2026-04-09 | — | — | US | claimed |
| EP-0235064-B1 | AROMATIC COMPOUNDS WITH AMIDE STRUCTURE, DERIVATIVES OF AMINO-BENZOIC ACIDS, HYDROXYBENZOIC ACIDS, CINNAMIC ACIDS, UROCANIC ACIDS AND BENZIMIDAZOLES, ABSORBING UVB AND/OR UVA | Robert, Dominique (FR) | 1992-06-17 | — | — | EP | claimed |
| US-5118707-A | Compositions for regulating skin wrinkles comprising a benzofuran derivative | THE PROCTER & GAMBLE COMPANY (US) | 1992-06-02 | — | — | US | claimed |
| WO-1991013100-A1 | CYCLODEXTRIN COMPOSITIONS AND METHODS FOR PHARMACEUTICAL AND INDUSTRIAL APPLICATIONS | AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMITED (AU) | 1991-09-05 | — | — | WO | claimed |
| WO-1991004026-A1 | DRUG DELIVERY COMPOSITIONS | AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMITED (AU) | 1991-04-04 | — | — | WO | claimed |
| US-4962095-A | Method of reducing pre-and post-ischemic myocardial arrhythmias and fibrillation | E. R. SQUIBB & SONS, INC. (US) | 1990-10-09 | — | — | US | claimed |
| EP-0383258-A2 | Pharmaceutical compositions for reducing pre and post-ischemic myocardial arrhythmias and fibrillation | E.R. SQUIBB & SONS, INC. (US) | 1990-08-22 | — | — | EP | claimed |
| US-4931464-A | ADMINISTERING ZOFENOPRIL OR ITS SALT | E. R. SQUIBB & SONS, INC. (US) | 1990-06-05 | — | — | US | claimed |
| EP-0335205-A1 | Catheter for retroinfusion of pharmalogical agents | Corday, Eliot, Dr. (US) | 1989-10-04 | — | — | EP | claimed |
| US-4689041-A | Retrograde delivery of pharmacologic and diagnostic agents via venous circulation | Corday, Eliot (US) | 1987-08-25 | — | — | US | claimed |
| EP-0150960-A2 | Catheter for retroinfusion of pharmacologic agents | Corday, Eliot, Dr. (US) | 1985-08-07 | — | — | EP | claimed |