Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amiodarone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | ATM | Q13315 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | SIRT3 | Q9NTG7 | 7/20 | 0.98 |
| ▸ | KDM5A | P29375 | 7/20 | 0.98 |
| ▸ | THRA | P10827 | 3/20 | 0.98 |
| ▸ | THRB | P10828 | 3/20 | 0.98 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amiodarone SCHEMBL41348 | 1.00 | ALDH1A1 (1.00) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL28989964 | 0.99 | ALDH1A1 (0.98) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL29361787 | 0.99 | SIRT3 (1.00) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL5496372 | 0.99 | SIRT3 (1.00) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL12487240 | 0.99 | SIRT3 (1.00) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL16284 | 0.99 | SIRT3 (1.00) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL28525007 | 0.98 | SIRT3 (0.98) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL29173757 | 0.98 | SIRT3 (0.98) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL29183902 | 0.98 | SIRT3 (0.98) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL19809514 | 0.97 | SIRT3 (0.96) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 359 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122053999-A | Pixel analog-to-digital conversion circuit and image sensor | 合肥海图微电子有限公司 | 2026-05-15 | — | — | CN | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| CN-117558178-B | Bee artificial insemination teaching system | 中国农业科学院蜜蜂研究所 | 2026-02-27 | — | — | CN | claimed |
| US-20250269005-A1 | METHODS FOR TREATING, AMELIORATING OR PREVENTING INFECTIONS USING DRUG AND VACCINATION COMBINATION TREATMENT | TOPELIA AUST LIMITED (ACN 652 771 670) (AU) | 2025-08-28 | — | — | US | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| US-20250207205-A1 | REAGENT, KIT, AND METHOD FOR DETECTING PIG ECONOMIC TRAIT-ASSOCIATED MUTATION SITE | AGRICULTURAL GENOMICS INSTITUTE AT SHENZHEN, CHINESE ACADEMY OF AGRICULTURAL SCIENCES (CN) | 2025-06-26 | — | — | US | claimed |
| CN-119759044-A | Cluster distributed collaborative task allocation method capable of being used for refusing environment | 中国航空工业集团公司洛阳电光设备研究所 | 2025-04-04 | — | — | CN | claimed |
| US-12257371-B2 | SiOx barrier for pharmaceutical package and coating process | SIO2 MEDICAL PRODUCTS, LLC (US) | 2025-03-25 | — | — | US | claimed |
| US-20240295545-A1 | GLIOMA THERAPY | IMPERIAL COLLEGE INNOVATIONS LTD (GB) | 2024-09-05 | — | — | US | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| WO-2022236364-A1 | METHODS FOR TREATING, AMELIORATING OR PREVENTING INFECTIONS USING DRUG AND VACCINATION COMBINATION TREATMENT | TOPELIA AUST LIMITED (ACN 652 771 670) (AU) | 2022-11-17 | — | — | WO | claimed |
| US-11471503-B2 | Use of KOR agonist in combination with MOR agonist in preparing drug for treating pain | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2022-10-18 | — | — | US | claimed |
| WO-2022172024-A1 | GLIOMA THERAPY | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2022-08-18 | — | — | WO | claimed |
| US-20220244247-A1 | PECVD COATED PHARMACEUTICAL PACKAGING | OAKTREE FUND ADMINISTRATION, LLC | 2022-08-04 | — | — | US | claimed |
| WO-2022126207-A1 | DRUGS, THERAPEUTIC COMBINATIONS AND METHODS FOR PREVENTING VIRAL AND MICROBIAL INFECTIONS AND THEIR SEQUELAE | TOPELIA AUST LIMITED (ACN 652 771 670) (AU) | 2022-06-23 | — | — | WO | claimed |
| WO-2022109619-A1 | POLYMER VIALS HAVING STANDARD EXTERNAL DIMENSIONS AND REDUCED INTERNAL VOLUME | SIO2 MEDICAL PRODUCTS, INC. (US) | 2022-05-27 | — | — | WO | claimed |
| US-20220161969-A1 | PASSIVATION, pH PROTECTIVE OR LUBRICITY COATING FOR PHARMACEUTICAL PACKAGE, COATING PROCESS AND APPARATUS | OAKTREE FUND ADMINISTRATION, LLC | 2022-05-26 | — | — | US | claimed |
| US-11298293-B2 | PECVD coated pharmaceutical packaging | SIO2 MEDICAL PRODUCTS, INC. (US) | 2022-04-12 | — | — | US | claimed |
| US-20220079950-A1 | THERAPEUTIC COMBINATIONS AS ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE | UNIV CALIFORNIA (US) | 2022-03-17 | — | — | US | claimed |
| CN-114104326-A | Unmanned aerial vehicle production method | 西北工业大学 | 2022-03-01 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11471503-B2 | Use of KOR agonist in combination with MOR agonist in preparing drug for treating pain | OPRK1, OPRM1, OPRL1 | KCNH2 396/4885ALDH1A1 2170/4885TP53 4871/4885 |
| US-20250269005-A1 | METHODS FOR TREATING, AMELIORATING OR PREVENTING INFECTIONS USING DRUG AND VACCINATION COMBINATION TREATMENT | ZFX, ACE2, ZFR | KCNH2 613/4885ALDH1A1 4660/4885TP53 44/4885 |
| US-20220079950-A1 | THERAPEUTIC COMBINATIONS AS ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE | SLC10A6, SLCO1B3, SLCO1B1 | KCNH2 1490/4885ALDH1A1 588/4885TP53 2408/4885 |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | MEN1, MYO1G, IL2 | KCNH2 2081/4885ALDH1A1 4095/4885TP53 3576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.