Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amiodarone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | ATM | Q13315 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | SIRT3 | Q9NTG7 | 7/20 | 0.98 |
| ▸ | KDM5A | P29375 | 7/20 | 0.98 |
| ▸ | THRA | P10827 | 3/20 | 0.98 |
| ▸ | THRB | P10828 | 3/20 | 0.98 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amiodarone SCHEMBL29362650 | 1.00 | ALDH1A1 (1.00) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL28989964 | 0.99 | ALDH1A1 (0.98) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL29361787 | 0.99 | SIRT3 (1.00) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL5496372 | 0.99 | SIRT3 (1.00) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL16284 | 0.99 | SIRT3 (1.00) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL12487240 | 0.99 | SIRT3 (1.00) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL29173757 | 0.98 | SIRT3 (0.98) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL29183902 | 0.98 | SIRT3 (0.98) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL28525007 | 0.98 | SIRT3 (0.98) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 | |
| Amiodarone SCHEMBL19809514 | 0.97 | SIRT3 (0.96) | ALDH1A1TP53CYP3A4SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3309 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-12533316-B2 | Parenteral dosage form of amiodarone | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2026-01-27 | — | — | US | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| CN-120136827-A | Preparation method of amiodarone hydrochloride | 珠海润都制药股份有限公司 | 2025-06-13 | — | — | CN | claimed |
| US-12257371-B2 | SiOx barrier for pharmaceutical package and coating process | SIO2 MEDICAL PRODUCTS, LLC (US) | 2025-03-25 | — | — | US | claimed |
| CN-119587526-A | New use of amiodarone or salt of amiodarone | 上海市第六人民医院 | 2025-03-11 | — | — | CN | claimed |
| CN-115844817-B | Amiodarone hydrochloride injection and preparation method thereof | 山东北大高科华泰制药有限公司 | 2025-03-04 | — | — | CN | claimed |
| CN-119235777-A | Amiodarone hydrochloride injection production and processing technology | 江苏神龙药业有限公司 | 2025-01-03 | — | — | CN | claimed |
| US-20240424196-A1 | INTEGRATED CARTRIDGE ASSEMBLY FOR ADMINISTRATION OF DRUGS | MEDPHLOW, LLC (US) | 2024-12-26 | — | — | US | claimed |
| CN-118496183-A | Synthesis method and application of amiodarone hydrochloride impurity F | 山东济坤生物制药有限公司 | 2024-08-16 | — | — | CN | claimed |
| WO-2001092208-A1 | METAL-CATALYSED CARBOXYMETHYLATION IN THE PRESENCE OF A PROMOTER | MONSANTO TECHNOLOGY LLC (US) | 2001-12-06 | — | — | WO | claimed |
| US-6221903-B1 | Amiodarone as an antifungal agent | UNIVERSITY AND COLLEGE OF NEVADA, RENO | 2001-04-24 | — | — | US | claimed |
| US-6187756-B1 | Composition and methods for treatment of neurological disorders and neurodegenerative diseases | THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2001-02-13 | — | — | US | claimed |
| US-6143778-A | COMPOSITION WITH BUFFERS AND NONIONIC SURFACTANTS | SANOFI (FR) | 2000-11-07 | — | — | US | claimed |
| WO-2000041688-A1 | USE OF AN AMIODARONE COMPOUND AS ANTIFUNGAL AGENT | THE BOARD OF REGENTS OF THE UNIVERSITY AND COMMUNITY COLLEGE SYSTEM OF NEVADA (US) | 2000-07-20 | — | — | WO | claimed |
| US-5985915-A | CARDIOVASCULAR DISORDERS SUCH AS ARRHYTHMIA | SANOFI (FR) | 1999-11-16 | — | — | US | claimed |
| CN-1213965-A | Use of antiarrhythmic compounds for reducing post-infarction morality | SANOFI SA (FR) | 1999-04-14 | — | — | CN | claimed |
| EP-0741570-A1 | METHOD FOR PREVENTING OR REDUCING PHOTOSENSITIVITY AND/OR PHOTOTOXICITY REACTIONS TO MEDICATIONS | G.D. SEARLE & CO. (US) | 1996-11-13 | — | — | EP | claimed |
| WO-1995020387-A1 | METHOD FOR PREVENTING OR REDUCING PHOTOSENSITIVITY AND/OR PHOTOTOXICITY REACTIONS TO MEDICATIONS | G.D. SEARLE & CO. (US) | 1995-08-03 | — | — | WO | claimed |
| WO-1995009625-A1 | USE OF AMIODARONE FOR THE TREATMENT OF HEART FAILURE | HANDFORTH INVESTMENTS LTD. (GB) | 1995-04-13 | — | — | WO | claimed |