Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.36 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | APP | P05067 | 4/20 | 0.33 |
| ▸ | SNCA | P37840 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 5/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 6/20 | 0.31 |
| ▸ | RARA | P10276 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11332332 | 0.81 | CYP1A2 (0.36) | CYP1A2ALDH1A1PTGS1DRD3LMNA | |
| SCHEMBL11323414 | 0.80 | CYP1A2 (0.35) | CYP1A2ALDH1A1PTGS1DRD3LMNA | |
| SCHEMBL11314530 | 0.77 | CYP1A2 (0.36) | CYP1A2ALDH1A1PTGS1DRD3LMNA | |
| SCHEMBL14879979 | 0.77 | CYP1A2 (0.39) | CYP1A2ALDH1A1PTGS1DRD3LMNA | |
| SCHEMBL11356731 | 0.76 | CYP1A2 (0.38) | CYP1A2ALDH1A1PTGS1DRD3LMNA | |
| SCHEMBL11356723 | 0.76 | CYP1A2 (0.38) | CYP1A2ALDH1A1PTGS1DRD3LMNA | |
| SCHEMBL12813207 | 0.76 | CYP1A2 (0.35) | CYP1A2ALDH1A1PTGS1DRD3LMNA | |
| SCHEMBL11447651 | 0.76 | CYP1A2 (0.38) | CYP1A2ALDH1A1PTGS1DRD3LMNA | |
| SCHEMBL14880058 | 0.76 | CYP1A2 (0.38) | CYP1A2ALDH1A1PTGS1DRD3LMNA | |
| SCHEMBL11448948 | 0.76 | CYP1A2 (0.35) | CYP1A2ALDH1A1PTGS1DRD3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768307-B1 | OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE | BIKAM PHARMACEUTICALS INC (US) | 2020-03-18 | — | — | EP | disclosed |
| US-20170137398-A1 | OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE | BIKAM PHARMACEUTICALS, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-9499464-B2 | Opsin-binding ligands, compositions and methods of use | BIKAM PHARMACEUTICALS, INC. (US) | 2016-11-22 | — | — | US | disclosed |
| US-20140256782-A1 | Opsin-Binding Ligands, Compositions and Methods of Use | BIKAM PHARMACEUTICALS, INC. (US) | 2014-09-11 | — | — | US | disclosed |
| EP-2768307-A1 | OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE | Bikam Pharmaceuticals, Inc. (US) | 2014-08-27 | — | — | EP | disclosed |
| US-8460635-B2 | Fenretinide derivatives and uses thereof as therapeutic, diagnostic and imaging agents | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2013-06-11 | — | — | US | disclosed |
| US-8460635-B2 | Fenretinide derivatives and uses thereof as therapeutic, diagnostic and imaging agents | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2013-06-11 | — | — | US | disclosed |
| US-8460635-B2 | Fenretinide derivatives and uses thereof as therapeutic, diagnostic and imaging agents | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2013-06-11 | — | — | US | disclosed |
| WO-2013058809-A1 | OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE | BIKAM PHARMACEUTICALS, INC. (US) | 2013-04-25 | — | — | WO | disclosed |
| US-20110091383-A1 | FENRETINIDE DERIVATIVES AND USES THEREOF AS THERAPEUTIC, DIAGNOSTIC AND IMAGING AGENTS | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2011-04-21 | — | — | US | disclosed |
| US-20110091383-A1 | FENRETINIDE DERIVATIVES AND USES THEREOF AS THERAPEUTIC, DIAGNOSTIC AND IMAGING AGENTS | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2011-04-21 | — | — | US | disclosed |
| US-20110091383-A1 | FENRETINIDE DERIVATIVES AND USES THEREOF AS THERAPEUTIC, DIAGNOSTIC AND IMAGING AGENTS | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2011-04-21 | — | — | US | disclosed |
| WO-2009114136-A2 | FENRETINIDE DERIVATIVES AND USES THEREOF AS THERAPEUTIC, DIAGNOSTIC AND IMAGING AGENTS | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170137398-A1 | OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE | CRYAB, CRYAA, PDE6C | CYP1A2 4420/4885ALDH1A1 2166/4885PTGS1 1994/4885 |
| US-20140256782-A1 | Opsin-Binding Ligands, Compositions and Methods of Use | CRYAB, PDE6C, CRYAA | CYP1A2 4370/4885ALDH1A1 2291/4885PTGS1 1907/4885 |
| US-20110091383-A1 | FENRETINIDE DERIVATIVES AND USES THEREOF AS THERAPEUTIC, DIAGNOSTIC AND IMAGING AGENTS | RBP4, HDLBP, PON1 | CYP1A2 2196/4885ALDH1A1 1479/4885PTGS1 1921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.