Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5754740 | 0.84 | GLO1 (0.46) | HPGDALOX15GLO1CYP1A2CYP2C9 | |
| SCHEMBL5753353 | 0.84 | GLO1 (0.46) | HPGDALOX15GLO1CYP1A2CYP2C9 | |
| SCHEMBL6960592 | 0.84 | GLO1 (0.46) | HPGDGLO1CYP1A2CYP2C9PTGS2 | |
| SCHEMBL6960584 | 0.84 | GLO1 (0.46) | HPGDGLO1CYP1A2CYP2C9PTGS2 | |
| SCHEMBL5753360 | 0.84 | GLO1 (0.46) | HPGDALOX15GLO1CYP1A2CYP2C9 | |
| SCHEMBL11547520 | 0.83 | GLO1 (0.57) | GLO1CYP1A2CYP2C9PTGS2FBP1 | |
| SCHEMBL15026456 | 0.83 | MAPT (0.45) | GLO1CYP1A2CYP2C9PTGS2FBP1 | |
| SCHEMBL15026370 | 0.81 | GLO1 (0.65) | HPGDGLO1CYP1A2CYP2C9PTGS2 | |
| SCHEMBL2424030 | 0.81 | GLO1 (0.65) | HPGDGLO1CYP1A2CYP2C9PTGS2 | |
| SCHEMBL2424031 | 0.81 | GLO1 (0.65) | HPGDGLO1CYP1A2CYP2C9PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9284330-B2 | 1,4-dihydro-naphthyridine derivative and pharmaceutical composition and use thereof | JIANGSU SIMOVAY PHARMACEUTICAL CO., LTD. (CN) | 2016-03-15 | — | — | US | disclosed |
| US-20140364443-A1 | 1,4-DIHYDRO-NAPHTHYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | JIANGSU SIMOVAY PHARMACEUTICAL CO., LTD. (CN) | 2014-12-11 | — | — | US | disclosed |
| US-20140364443-A1 | 1,4-DIHYDRO-NAPHTHYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | JIANGSU SIMOVAY PHARMACEUTICAL CO., LTD. (CN) | 2014-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364443-A1 | 1,4-DIHYDRO-NAPHTHYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | ACHE, BACE1, CACNA1D | HPGD 182/4885ALOX15 1952/4885GLO1 2229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.