Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GLO1 | Q04760 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16285261 | 0.85 | GLO1 (0.65) | MAPTGLO1MEN1KMT2ALMNA | |
| SCHEMBL11550212 | 0.82 | GLO1 (0.75) | MAPTGLO1MEN1KMT2ALMNA | |
| SCHEMBL11550206 | 0.82 | GLO1 (0.75) | MAPTGLO1MEN1KMT2ALMNA | |
| SCHEMBL15026451 | 0.82 | GLO1 (0.49) | MAPTGLO1MEN1KMT2ALMNA | |
| SCHEMBL9383562 | 0.81 | GLO1 (0.49) | MAPTGLO1PTGS1AKR1C2HPGD | |
| SCHEMBL6955892 | 0.81 | GLO1 (0.49) | MAPTGLO1PTGS1AKR1C2HPGD | |
| SCHEMBL15026456 | 0.77 | MAPT (0.45) | MAPTGLO1MEN1KMT2ALMNA | |
| SCHEMBL5751671 | 0.72 | PTGS1 (0.47) | MAPTGLO1CYP1A2PTGS1NPC1 | |
| SCHEMBL5753235 | 0.72 | PTGS1 (0.47) | MAPTGLO1CYP1A2PTGS1NPC1 | |
| SCHEMBL5751673 | 0.72 | PTGS1 (0.47) | MAPTGLO1CYP1A2PTGS1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9284330-B2 | 1,4-dihydro-naphthyridine derivative and pharmaceutical composition and use thereof | JIANGSU SIMOVAY PHARMACEUTICAL CO., LTD. (CN) | 2016-03-15 | — | — | US | disclosed |
| US-20140364443-A1 | 1,4-DIHYDRO-NAPHTHYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | JIANGSU SIMOVAY PHARMACEUTICAL CO., LTD. (CN) | 2014-12-11 | — | — | US | disclosed |
| US-20140364443-A1 | 1,4-DIHYDRO-NAPHTHYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | JIANGSU SIMOVAY PHARMACEUTICAL CO., LTD. (CN) | 2014-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364443-A1 | 1,4-DIHYDRO-NAPHTHYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | ACHE, BACE1, CACNA1D | MAPT 181/4885GLO1 2229/4885MEN1 2207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.