Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | KLK7 | P49862 | 2/20 | 0.54 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL5175781 | 0.96 | MAPT (0.66) | SYKMAPTKLK7KLK5HTT | |
| SCHEMBL29869484 | 0.93 | SYK (0.71) | SYKMAPTKLK7KLK5HTT | |
| SCHEMBL20364084 | 0.92 | SYK (0.74) | SYKMAPTKLK7KLK5ITGB3 | |
| SCHEMBL21790401 | 0.91 | MAPT (0.63) | SYKMAPTKLK7KLK5HTT | |
| SCHEMBL21789935 | 0.91 | MAPT (0.63) | SYKMAPTKLK7KLK5HTT | |
| SCHEMBL2512643 | 0.91 | MAPT (0.63) | SYKMAPTKLK7KLK5HTT | |
| SCHEMBL16279057 | 0.90 | MAPT (0.62) | SYKMAPTKLK7KLK5HTT | |
| SCHEMBL16082984 | 0.90 | SYK (0.61) | SYKMAPTKLK7KLK5HTT | |
| SCHEMBL1024150 | 0.90 | MAPT (0.62) | SYKMAPTKLK7KLK5HTT | |
| SCHEMBL19295567 | 0.90 | SYK (0.71) | SYKMAPTKLK7KLK5HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140364642-A1 | COMPOUND HAVING READ-THROUGH ACTIVITY | THE UNIVERSITY OF TOKYO (JP) | 2014-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364642-A1 | COMPOUND HAVING READ-THROUGH ACTIVITY | UPF1, NUDT21, GBA2 | SYK 4808/4885MAPT 3268/4885KLK7 3726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.