Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL436372 | 0.85 | TSHR (0.33) | ADORA2APTGDR2MPOALDH1A1MAPT | |
| SCHEMBL434274 | 0.82 | SLC40A1 (0.35) | ALDH1A1MAPTKEAP1NFE2L2CYP1A1 | |
| SCHEMBL16289961 | 0.75 | MAOA (0.34) | ALDH1A1MAPTNPSR1KEAP1NFE2L2 | |
| SCHEMBL18784225 | 0.70 | G6PD (0.40) | MAPTKEAP1NFE2L2 | |
| SCHEMBL16289748 | 0.67 | NPC1 (0.31) | ALDH1A1 | |
| SCHEMBL436444 | 0.66 | KDM4E (0.42) | ALDH1A1MAPTNPSR1 | |
| SCHEMBL16289891 | 0.66 | MAPT (0.31) | ALDH1A1MAPT | |
| SCHEMBL434719 | 0.62 | TSHR (0.35) | ALDH1A1MAPTNPSR1 | |
| SCHEMBL18784226 | 0.62 | KMT2A (0.46) | ALDH1A1KEAP1NFE2L2HSD11B1 | |
| SCHEMBL27867868 | 0.61 | G6PD (0.41) | KEAP1NFE2L2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595988-B1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | ZAFGEN INC (US) | 2014-12-17 | — | — | EP | claimed |