Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16290712 | 1.00 | KDM4E (0.50) | KDM4EGLAEIF2AK2CSNK2A2CSNK2B | |
| SCHEMBL5862650 | 0.81 | EIF2AK2 (0.55) | KDM4EGLAEIF2AK2CSNK2A2CSNK2B | |
| SCHEMBL5862648 | 0.81 | EIF2AK2 (0.55) | KDM4EGLAEIF2AK2CSNK2A2CSNK2B | |
| SCHEMBL14402828 | 0.80 | MAPT (0.49) | KDM4EGLAMAPTPOLBNPSR1 | |
| SCHEMBL6098213 | 0.80 | MIF (0.59) | KDM4EGLAMAPTPOLBNPSR1 | |
| SCHEMBL3864311 | 0.80 | ERN1 (0.58) | KDM4EGLAEIF2AK2CSNK2A2CSNK2B | |
| SCHEMBL6098209 | 0.80 | MIF (0.59) | KDM4EGLAMAPTPOLBNPSR1 | |
| SCHEMBL15866178 | 0.80 | TDO2 (0.55) | KDM4EEIF2AK2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL18046005 | 0.80 | TDO2 (0.55) | KDM4EEIF2AK2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL3864314 | 0.80 | ERN1 (0.58) | KDM4EGLAEIF2AK2CSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11807634-B2 | Cyclopropyl dihydroquinoline sulfonamide compounds | AMGEN INC. (US) | 2023-11-07 | — | — | US | disclosed |
| US-20230234948-A1 | CYCLOPROPYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2023-07-27 | — | — | US | disclosed |
| US-20230227442-A1 | HETEROALKYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2023-07-20 | — | — | US | disclosed |
| EP-4165032-A1 | HETEROALKYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | Amgen Inc. (US) | 2023-04-19 | — | — | EP | disclosed |
| EP-4165024-A1 | CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | Amgen Inc. (US) | 2023-04-19 | — | — | EP | disclosed |
| EP-4164748-A1 | CYCLOPROPYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | Amgen Inc. (US) | 2023-04-19 | — | — | EP | disclosed |
| CN-115697971-A | Cyclobutyldihydroquinoline sulfonamide compound | 美国安进公司 | 2023-02-03 | — | — | CN | disclosed |
| US-20220306604-A1 | CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2022-09-29 | — | — | US | disclosed |
| WO-2021252818-A1 | CYCLOPROPYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2021-12-16 | — | — | WO | disclosed |
| WO-2021252822-A1 | HETEROALKYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2021-12-16 | — | — | WO | disclosed |
| EP-3390393-A1 | ALKYNYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | Amgen Inc. (US) | 2018-10-24 | — | — | EP | disclosed |
| EP-3390392-A1 | ALKYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | Amgen Inc. (US) | 2018-10-24 | — | — | EP | disclosed |
| WO-2017106871-A1 | ALKYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2017-06-22 | — | — | WO | disclosed |
| WO-2017106872-A1 | ALKYNYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC (US) | 2017-06-22 | — | — | WO | disclosed |
| US-9458152-B2 | Bicyclic sulfonamide compounds as sodium channel inhibitors | AMGEN INC. (US) | 2016-10-04 | — | — | US | disclosed |
| EP-3008057-A1 | BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | Amgen Inc. (US) | 2016-04-20 | — | — | EP | disclosed |
| US-20160046626-A1 | BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | AMGEN INC. | 2016-02-18 | — | — | US | disclosed |
| US-9212182-B2 | Bicyclic sulfonamide compounds as sodium channel inhibitors | AMGEN INC. (US) | 2015-12-15 | — | — | US | disclosed |
| WO-2014201206-A1 | BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | AMGEN INC. (US) | 2014-12-18 | — | — | WO | disclosed |
| US-20140371201-A1 | BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | AMGEN INC. | 2014-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140371201-A1 | BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | SCN7A, TRPV1, TRPV5 | KDM4E 2549/4885GLA 4097/4885EIF2AK2 3645/4885 |
| US-20160046626-A1 | BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | SCN7A, TRPV1, TRPV5 | KDM4E 2549/4885GLA 4097/4885EIF2AK2 3645/4885 |
| US-20230227442-A1 | HETEROALKYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | SCN7A, TRPV1, SCNN1A | KDM4E 3313/4885GLA 4539/4885EIF2AK2 2000/4885 |
| US-20230234948-A1 | CYCLOPROPYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | TRPV1, SCN7A, TRPA1 | KDM4E 3420/4885GLA 4579/4885EIF2AK2 2793/4885 |
| US-11807634-B2 | Cyclopropyl dihydroquinoline sulfonamide compounds | TRPV1, SCN7A, TRPA1 | KDM4E 3284/4885GLA 4642/4885EIF2AK2 2740/4885 |
| US-20220306604-A1 | CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | TRPV1, SCN7A, TRPA1 | KDM4E 3449/4885GLA 4691/4885EIF2AK2 2806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.