Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL11258995 | 0.91 | TSHR (0.47) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL27660591 | 0.86 | TSHR (0.53) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL27981758 | 0.84 | TSHR (0.50) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL179840 | 0.81 | NAPRT (0.60) | TSHRNAPRTTDP1TAAR1FFAR3 | |
| Pyridine SCHEMBL10977701 | 0.81 | NAPRT (0.60) | TSHRNAPRTTDP1TAAR1FFAR3 | |
| Pyridine SCHEMBL11125163 | 0.81 | NAPRT (0.60) | TSHRNAPRTTDP1TAAR1FFAR3 | |
| Tetrahydrothiophene SCHEMBL9158780 | 0.81 | — | — | |
| Pyridine SCHEMBL14645659 | 0.81 | TSHR (0.60) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL4558243 | 0.78 | NAPRT (0.56) | TSHRNAPRTTDP1TAAR1FFAR3 | |
| Pyridine SCHEMBL5844201 | 0.78 | NAPRT (0.56) | TSHRNAPRTTDP1TAAR1FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080249311-A1 | Using halogen phenyl acetonitrile as starting material; tetrahydrothienopyridine (acetate or acetonitrile) as chemical intermediates; kinetic resolution; anticoagulant | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2008-10-09 | — | — | US | claimed |
| EP-1942110-A1 | PREPARATION OF CLOPIDOGREL AND ITS ANALOGUES METHYL TETRAHYDROTHIENOPYRIDINE ACETATE COMPOUNDS | Zhejiang Huahai Pharmaceutical Co., Ltd. (CN) | 2008-07-09 | — | — | EP | claimed |
| US-7932391-B2 | Using halogen phenyl acetonitrile as starting material; tetrahydrothienopyridine (acetate or acetonitrile) as chemical intermediates; kinetic resolution; anticoagulant | Zhejiang Hauhai Pharmaceutical Co., Ltd. (CN) | 2011-04-26 | — | — | US | disclosed |
| US-20080249311-A1 | Using halogen phenyl acetonitrile as starting material; tetrahydrothienopyridine (acetate or acetonitrile) as chemical intermediates; kinetic resolution; anticoagulant | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2008-10-09 | — | — | US | disclosed |
| EP-1942110-A1 | PREPARATION OF CLOPIDOGREL AND ITS ANALOGUES METHYL TETRAHYDROTHIENOPYRIDINE ACETATE COMPOUNDS | Zhejiang Huahai Pharmaceutical Co., Ltd. (CN) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007028337-A1 | PREPARATION OF CLOPIDOGREL AND ITS ANALOGUES METHYL TETRAHYDROTHIENOPYRIDINE ACETATE COMPOUNDS | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249311-A1 | Using halogen phenyl acetonitrile as starting material; tetrahydrothienopyridine (acetate or acetonitrile) as chemical intermediates; kinetic resolution; anticoagulant | TFPI, F2, CYP2C19 | TSHR 259/4885NAPRT 2752/4885TDP1 913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.