SCHEMBL162916

SCHEMBL162916

CSC(=O)O/C(=C(/C#N)c1ccc(Cl)cc1)c1ccccc1C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 2/20 0.42
GAA P10253 2/20 0.35
PPARG P37231 2/20 0.35
CNR1 P21554 1/20 0.35
PPARA Q07869 1/20 0.35
LTC4S Q16873 1/20 0.35
TRPA1 O75762 1/20 0.34
LMNA P02545 1/20 0.34
MAPT P10636 1/20 0.34
NPC1 O15118 1/20 0.34
POLB P06746 1/20 0.34
GRIK1 P39086 1/20 0.33
KMT2A Q03164 1/20 0.33
P2RX7 Q99572 1/20 0.33
SCD O00767 1/20 0.32
KDM4E B2RXH2 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C19 P33261 1/20 0.32
RAB9A P51151 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7070108 0.93 MGLL (0.41) MGLLGAAPPARGCNR1PPARA
SCHEMBL7235547 0.88 MEN1 (0.37) GAAPPARGLMNAMAPTNPC1
SCHEMBL7235541 0.88 MEN1 (0.37) GAAPPARGLMNAMAPTNPC1
SCHEMBL7071399 0.87 MGLL (0.39) MGLLGAAPPARGCNR1PPARA
SCHEMBL7071370 0.86 MGLL (0.45) MGLLGAAPPARGPPARALTC4S
SCHEMBL7071368 0.86 MGLL (0.45) MGLLGAAPPARGPPARALTC4S
SCHEMBL28357691 0.82 MGLL (0.40) MGLLGAAPPARGPPARALTC4S
SCHEMBL7071961 0.81 MGLL (0.41) MGLLGAAPPARGPPARALTC4S
SCHEMBL7070073 0.80 MGLL (0.38) MGLLGAAPPARGPPARALTC4S
SCHEMBL7070072 0.80 MGLL (0.38) MGLLGAAPPARGPPARALTC4S

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 217 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210282405-A1 ALGICIDAL ORGANISMS MARRONE BIO INNOVATIONS, INC. (US) 2021-09-16 US claimed
US-RE48057-E1 Pesticidal compositions and related methods DOW AGROSCIENCES LLC (US) 2020-06-23 US claimed
CN-107072206-B Pesticidal compositions and related methods 美国陶氏益农公司 2020-02-21 CN claimed
EP-3145312-B1 PESTICIDAL COMPOSITIONS AND RELATED METHODS DOW AGROSCIENCES LLC (US) 2019-11-20 EP claimed
EP-3062619-B1 PESTICIDAL COMPOSITIONS AND RELATED METHODS DOW AGROSCIENCES LLC (US) 2019-07-24 EP claimed
EP-2934135-B1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2018-01-31 EP claimed
EP-2934142-B1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2018-01-31 EP claimed
US-20170267629-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-09-21 US claimed
US-20170158597-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-06-08 US claimed
US-20170158624-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-06-08 US claimed
US-20130072382-A1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2013-03-21 US claimed
US-20130019348-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2013-01-17 US claimed
US-8350044-B2 Pesticidal compositions DOW AGROSCIENCES, LLC. (US) 2013-01-08 US claimed
US-20120329649-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC 2012-12-27 US claimed
US-20120110701-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2012-05-03 US claimed
US-20120110702-A1 Pesticidal Compositions and Processes Related Thereto CORTEVA AGRISCIENCE LLC 2012-05-03 US claimed
EP-2427191-A1 PESTICIDAL COMPOSITIONS Dow AgroSciences LLC (US) 2012-03-14 EP claimed
US-20100292253-A1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2010-11-18 US claimed
WO-2010129497-A1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2010-11-11 WO claimed
US-20100197737-A1 ACTIVE AGENT COMBINATIONS HAVING INSECTICIDAL AND ACARICIDAL PROPERTIES BAYER CROPSCIENCE AG (DE) 2010-08-05 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170158624-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS MGLL 214/4885GAA 1052/4885PPARG 1158/4885
US-20170267629-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS MGLL 214/4885GAA 1052/4885PPARG 1158/4885
US-20170158597-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS MGLL 214/4885GAA 1052/4885PPARG 1158/4885
US-20100197737-A1 ACTIVE AGENT COMBINATIONS HAVING INSECTICIDAL AND ACARICIDAL PROPERTIES ACHE, AADAC, AMY1A MGLL 390/4885GAA 67/4885PPARG 2952/4885
US-20120110701-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, AGPS, DDT MGLL 346/4885GAA 1260/4885PPARG 1592/4885
US-20100292253-A1 PESTICIDAL COMPOSITIONS ACHE, DDT, PRDX6 MGLL 332/4885GAA 2045/4885PPARG 2473/4885
US-20120329649-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS MGLL 214/4885GAA 1052/4885PPARG 1158/4885
US-20130072382-A1 PESTICIDAL COMPOSITIONS ACHE, DDT, PRDX6 MGLL 332/4885GAA 2045/4885PPARG 2473/4885
US-20130019348-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, CAT MGLL 56/4885GAA 350/4885PPARG 1436/4885
US-20120110702-A1 Pesticidal Compositions and Processes Related Thereto ACHE, DDT, PTMS MGLL 301/4885GAA 1186/4885PPARG 1196/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.